Proposal for a definition of

BMC Cancer

Table 3 Summary of all criteria as proposed by us for the definition of the oligometastatic disease in pancreatic cancer

Criteria for Oligometastatic Disease in Pancreatic Ductal Adenocarcinoma
	Inclusion	Exclusion
ECOG	0/1	>/= 2
Liver/lung only (+LN hepatoduodenal lig.)	Yes	No
Number of hepatic or pulmonary lesions	</= 4	> 4
Ascites	No	Yes
Liver cirrhosis	No	Yes
Lung emphysema	No	Yes
CA 19–9 (U/mL)^a	< 1000	> 1000
Surgery for metastasis^b	Atypical resection (+/−Ablation)	Non-resectable/major hepatic/lung surgery necessary
Primary tumor upon diagnosis^b	Resectable, borderline resectable, non-resectable^c
Chemotherapy response	Response or stable disease	Progressive disease

^aHartwig et al. 2013 Ann Surg Oncol (2013) 20:2188–2196; DOI 10.1245/s10434-012-2809-1: R0 Resection rate CA 19-9 > 1000U/ml as low as 15%
^bResectability of primary tumor and expected extension of hepatic resection to be evaluated by experienced HPB surgeon together with a radiologist
^cAs defined in: Isaji, S. et al. International consensus on definition and criteria of borderline resectable pancreatic ductal adenocarcinoma 2017. Pancreatology 18, (2018)

ISSN: 1471-2407