Fig. 7

Numbl regulates CAM-DR process in myeloma cells through interaction with Integrin β1. a In the adhesion model of myeloma cells, after alterating the interaction between Numbl and Integrin β1, myeloma cell activity with different drugs was assessed. *,# compared with the control group, P < 0.05. b After the alteration of the Numbl expression and the interaction between Numbl and Integrin β1, we probed for the expression of Caspase-3 and Bcl-2 in myeloma cell adhesion-mediated drug resistance model through Western Blot analysis. c Flow cytometry was used to measure the cell apoptosis in a cell adhesion-mediated drug resistance model. *, # compared with the control group (HA-Numbl compared with HA group and RNAi compared with Ctrl group, respectively), P < 0.05