Fig. 1

Chest imaging findings, Chest imaging at baseline (a-c), and after 13 rounds of nivolumab treatment (d-f), On the chest x-ray, primary tumor was shown in the upper lung field in contact with upper mediastinum (arrow heads), and disseminated tumor masses were mainly identified in the left lower lung field as a consolidated area (black dotted heads) (a) and were improved after nivolumab therapy (d). On the chest computed tomography image, the primary lesion in the left upper lobe adjacent to mediastinum (black arrow heads), disseminated multiple masses in the thoracic cavity (black solid arrows), and pleural and interlobular septal thickening due to lymphatic spread of tumors (black dotted arrows) (b, c) were all improved after nivolumab therapy (e, f)