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Table 4 Univariate and multivariate Cox analysis for association between methylation and OS in 307 CRC patients

From: DNA methylation of SFRP1, SFRP2, and WIF1 and prognosis of postoperative colorectal cancer patients

VariablesNumberUnivariate CoxMultivariate CoxPropensity score-1Propensity score-2
Patients (N = 307)Deaths (N = 127)Crude HR (95% CI)P valueAdjusted HR a
(95% CI)
P valueAdjusted HR a (95% CI)P valueAdjusted HR b (95% CI)P value
SFRP1   0.001 0.070 0.084 0.096
 Hypomethylation55311.000 1.000 1.000 1.000 
 Hypermethylation252960.505 (0.336–0.760) 0.672 (0.437–1.032) 0.686 (0.447–1.051) 0.688 (0.443–1.069) 
SFRP2   0.001 0.005 0.015 0.034
 Hypomethylation2641191.000 1.000 1.000 1.000 
 Hypermethylation4380.307 (0.149–0.633) 0.343 (0.164–0.718) 0.410 (0.200–0.842) 0.455 (0.219–0.944) 
WIF1   0.399 0.688  
 Hypomethylation224981.000 1.000   
 Hypermethylation83290.836 (0.552–1.267) 1.092 (0.710–1.682)   
Co-methylation-2   0.001 0.003 0.013 0.030
 Co-methylation-2 L c2641191.000 1.000 1.000 1.000 
 Co-methylation-2H d4380.298 (0.145–0.612) 0.333 (0.159–0.694) 0.398 (0.192–0.821) 0.442 (0.212–0.923) 
Co-methylation-3   0.018 0.032 0.077 0.155
 Co-methylation-3 L e2841231.000 1.000 1.000 1.000 
 Co-methylation-3H f2340.300 (0.110–0.814) 0.326 (0.117–0.908) 0.401 (0.146–1.106) 0.479 (0.174–1.321) 
  1. aControlling for the variables which included age, gender, CEA, CA19–9, TNM staging, pathological classification, differentiation degree and postoperative radiotherapy
  2. bControlling for the variables which included age, gender, CEA, CA19–9, multiple polyps, tumor location, TNM staging, pathological classification, histologic classification, differentiation degree, postoperative chemotherapy and postoperative radiotherapy
  3. cCo-methylation-2 L: patients with promoter hypomethylation of at least one gene (SFRP1 or SFRP2)
  4. dCo-methylation-2H: patients with promoter hypermethylation of SFRP1 and SFRP2
  5. eCo-methylation-3 L: patients with promoter hypomethylation of at least one gene (SFRP1 or SFRP2 or WIF1)
  6. fCo-methylation-3H: patients with promoter hypermethylation of SFRP1, SFRP2 and WIF1