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Table 3 The overall survival rates at 1, 3, 5 and 8 year in groups stratified by methylation in tumor tissues (N = 307)

From: DNA methylation of SFRP1, SFRP2, and WIF1 and prognosis of postoperative colorectal cancer patients

Groups1 year3 year5 year8 year
OSR (SE) aP valueOSR (SE)P valueOSR (SE)P valueOSR (SE)P value
All patients (N = 307)0.915 (0.018) 0.748 (0.027) 0.646 (0.028) 0.518 (0.039) 
SFRP1 0.229 0.071 0.005 0.003
 Hypomethylation (N = 55)0.872 (0.052) 0.660 (0.070) 0.472 (0.071) 0.258 (0.116) 
 Hypermethylation (N = 252)0.925 (0.019) 0.767 (0.030) 0.683 (0.031) 0.562 (0.042) 
SFRP2 0.205 0.015 0.001 0.000
 Hypomethylation (N = 246)0.905 (0.021) 0.720 (0.031) 0.603 (0.032) 0.455 (0.048) 
 Hypermethylation (N = 43)0.976 (0.023) 0.928 (0.040) 0.904 (0.046) 0.822 (0.062) 
WIF1 0.044 0.477 0.793 0.598
 Hypomethylation (N = 224)0.932 (0.020) 0.755 (0.032) 0.627 (0.034) 0.491 (0.046) 
 Hypermethylation (N = 83)0.868 (0.041) 0.730 (0.055) 0.700 (0.051) 0.595 (0.073) 
Co-methylation-2 0.205 0.015 0.001 0.000
 Co-methylation-2 L b0.905 (0.020) 0.720 (0.031) 0.603 (0.032) 0.462 (0.044) 
 Co-methylation-2H c0.976 (0.023) 0.928 (0.040) 0.904 (0.046) 0.822 (0.062) 
Co-methylation-3 0.624 0.111 0.013 0.004
 Co-methylation-3 L d0.912 (0.019) 0.735 (0.029) 0.623 (0.030) 0.493 (0.039) 
 Co-methylation-3H e0.957 (0.043) 0.913 (0.059) 0.913 (0.059) 0.852 (0.080) 
  1. aOverall Survival Rate (Standard Error)
  2. bCo-methylation-2 L: patients with promoter hypomethylation of at least one gene (SFRP1 or SFRP2)
  3. cCo-methylation-2H: patients with promoter hypermethylation of SFRP1 and SFRP2
  4. dCo-methylation-3 L: patients with promoter hypomethylation of at least one gene (SFRP1 or SFRP2 or WIF1)
  5. eCo-methylation-3H: patients with promoter hypermethylation of SFRP1, SFRP2 and WIF1