DNA methylation of SFRP1, SFRP2, and WIF1 and prognosis of postoperative colorectal cancer patients

BMC Cancer

Table 3 The overall survival rates at 1, 3, 5 and 8 year in groups stratified by methylation in tumor tissues (N = 307)

Groups	1 year		3 year		5 year		8 year
Groups	OSR (SE) ^a	P value	OSR (SE)	P value	OSR (SE)	P value	OSR (SE)	P value
All patients (N = 307)	0.915 (0.018)		0.748 (0.027)		0.646 (0.028)		0.518 (0.039)
SFRP1		0.229		0.071		0.005		0.003
Hypomethylation (N = 55)	0.872 (0.052)		0.660 (0.070)		0.472 (0.071)		0.258 (0.116)
Hypermethylation (N = 252)	0.925 (0.019)		0.767 (0.030)		0.683 (0.031)		0.562 (0.042)
SFRP2		0.205		0.015		0.001		0.000
Hypomethylation (N = 246)	0.905 (0.021)		0.720 (0.031)		0.603 (0.032)		0.455 (0.048)
Hypermethylation (N = 43)	0.976 (0.023)		0.928 (0.040)		0.904 (0.046)		0.822 (0.062)
WIF1		0.044		0.477		0.793		0.598
Hypomethylation (N = 224)	0.932 (0.020)		0.755 (0.032)		0.627 (0.034)		0.491 (0.046)
Hypermethylation (N = 83)	0.868 (0.041)		0.730 (0.055)		0.700 (0.051)		0.595 (0.073)
Co-methylation-2		0.205		0.015		0.001		0.000
Co-methylation-2 L ^b	0.905 (0.020)		0.720 (0.031)		0.603 (0.032)		0.462 (0.044)
Co-methylation-2H ^c	0.976 (0.023)		0.928 (0.040)		0.904 (0.046)		0.822 (0.062)
Co-methylation-3		0.624		0.111		0.013		0.004
Co-methylation-3 L ^d	0.912 (0.019)		0.735 (0.029)		0.623 (0.030)		0.493 (0.039)
Co-methylation-3H ^e	0.957 (0.043)		0.913 (0.059)		0.913 (0.059)		0.852 (0.080)

^aOverall Survival Rate (Standard Error)
^bCo-methylation-2 L: patients with promoter hypomethylation of at least one gene (SFRP1 or SFRP2)
^cCo-methylation-2H: patients with promoter hypermethylation of SFRP1 and SFRP2
^dCo-methylation-3 L: patients with promoter hypomethylation of at least one gene (SFRP1 or SFRP2 or WIF1)
^eCo-methylation-3H: patients with promoter hypermethylation of SFRP1, SFRP2 and WIF1

ISSN: 1471-2407