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Table 3 Multivariate Cox regression model analyses of overall survival and cancer specific survival in the nomogram cohort

From: Nomograms to predict individual prognosis of patients with squamous cell carcinoma of the urinary bladder

CharacteristicsOverall Survival (OS)Cancer Specific Survival (CSS)
HRa (95% CIb)P-valueHR (95% CI)P-value
Age at diagnosis
 < 501(Reference) 1(Reference) 
 50–591.118 (0.833–1.499)0.4570.981 (0.725–1.328)0.902
 60–691.321 (0.990–1.764)0.0591.161 (0.856–1.573)0.338
 70–791.434 (1.089–1.888)0.0101.310 (0.981–1.750)0.067
 80–891.935 (1.458–2.568)< 0.0011.703 (1.263–2.297)< 0.001
 90–1002.181 (1.473–3.228)< 0.0012.115 (1.388–3.222)< 0.001
Marital status
 Married1 (Reference) 1 (Reference) 
 Single1.364 (1.176–1.583)< 0.0011.364 (1.16–1.604)< 0.001
 Unknown1.338 (0.956–1.872)0.0901.325 (0.916–1.915)0.135
Race
 Black1 (Reference) Not selected 
 White1.007 (0.819–1.238)0.946  
 Other0.811 (0.545–1.207)0.302  
Sex
 Female1 (Reference) 1 (Reference) 
 Male0.828 (0.719–0.953)0.0090.790 (0.677–0.922)0.003
Grade
 I1 (Reference) Not selected 
 II1.112 (0.904–1.368)0.314  
 III0.772 (0.652–0.914)0.003  
 IV0.995 (0.879–1.125)0.932  
T
 T11 (Reference) 1(Reference) 
 T21.394 (1.117–1.741)0.0031.304 (1.020–1.665)0.034
 T31.660 (1.265–2.177)< 0.0011.685 (1.251–2.270)0.001
 T42.234 (1.726–2.892)< 0.0012.104 (1.589–2.786)< 0.001
 Ta0.475 (0.174–1.299)0.1470.500 (0.157–1.593)0.241
 Tis0.815 (0.392–1.695)0.5840.560 (0.204–1.541)0.262
N
 N01 (Reference) 1 (Reference) 
 N11.354 (0.987–1.858)0.0601.241 (0.892–1.725)0.199
 N21.382 (1.013–1.886)0.0411.307 (0.951–1.795)0.098
 N31.439 (0.443–4.675)0.5451.907 (0.587–6.197)0.283
M
 M01 (Reference) 1 (Reference) 
 M12.358 (1.881–2.956)< 0.0012.285 (1.816–2.876)< 0.001
RCc
 No1 (Reference) 1 (Reference) 
 Yes0.433 (0.342–0.548)< 0.0010.436 (0.333–0.572)< 0.001
Chemotherapy
 No/unknown1 (Reference) Not selected 
 Yes0.605 (0.514–0.712)< 0.001  
Size
 ≤ 6.5 cm1 (Reference) 1 (Reference) 
 >6.5 cm1.815 (1.510–2.182)< 0.0011.840 (1.506–2.248)< 0.001
 Unknown1.509 (1.277–1.783)< 0.0011.510 (1.255–1.816)< 0.001
LNRd
 01 (Reference) 1 (Reference) 
 ≤ 0.03851.316 (0.578–2.993)0.5131.195 (0.460–3.100)0.714
 >0.03852.341 (1.629–3.363)< 0.0012.797 (1.895–4.130)< 0.001
 Unknown1.734 (1.328–2.263)< 0.0011.846 (1.359–2.509)< 0.001
  1. aHR Hazard ratio
  2. bCI Confidence interval
  3. cRC Radical cystectomy
  4. dLNR Lymph node ratio