Table 3 Multivariate Cox regression model analyses of overall survival and cancer specific survival in the nomogram cohort
Characteristics | Overall Survival (OS) | Cancer Specific Survival (CSS) | ||
|---|---|---|---|---|
HRa (95% CIb) | P-value | HR (95% CI) | P-value | |
Age at diagnosis | ||||
 < 50 | 1(Reference) |  | 1(Reference) |  |
 50–59 | 1.118 (0.833–1.499) | 0.457 | 0.981 (0.725–1.328) | 0.902 |
 60–69 | 1.321 (0.990–1.764) | 0.059 | 1.161 (0.856–1.573) | 0.338 |
 70–79 | 1.434 (1.089–1.888) | 0.010 | 1.310 (0.981–1.750) | 0.067 |
 80–89 | 1.935 (1.458–2.568) | < 0.001 | 1.703 (1.263–2.297) | < 0.001 |
 90–100 | 2.181 (1.473–3.228) | < 0.001 | 2.115 (1.388–3.222) | < 0.001 |
Marital status | ||||
 Married | 1 (Reference) |  | 1 (Reference) |  |
 Single | 1.364 (1.176–1.583) | < 0.001 | 1.364 (1.16–1.604) | < 0.001 |
 Unknown | 1.338 (0.956–1.872) | 0.090 | 1.325 (0.916–1.915) | 0.135 |
Race | ||||
 Black | 1 (Reference) |  | Not selected |  |
 White | 1.007 (0.819–1.238) | 0.946 |  |  |
 Other | 0.811 (0.545–1.207) | 0.302 |  |  |
Sex | ||||
 Female | 1 (Reference) |  | 1 (Reference) |  |
 Male | 0.828 (0.719–0.953) | 0.009 | 0.790 (0.677–0.922) | 0.003 |
Grade | ||||
 I | 1 (Reference) |  | Not selected |  |
 II | 1.112 (0.904–1.368) | 0.314 |  |  |
 III | 0.772 (0.652–0.914) | 0.003 |  |  |
 IV | 0.995 (0.879–1.125) | 0.932 |  |  |
T | ||||
 T1 | 1 (Reference) |  | 1(Reference) |  |
 T2 | 1.394 (1.117–1.741) | 0.003 | 1.304 (1.020–1.665) | 0.034 |
 T3 | 1.660 (1.265–2.177) | < 0.001 | 1.685 (1.251–2.270) | 0.001 |
 T4 | 2.234 (1.726–2.892) | < 0.001 | 2.104 (1.589–2.786) | < 0.001 |
 Ta | 0.475 (0.174–1.299) | 0.147 | 0.500 (0.157–1.593) | 0.241 |
 Tis | 0.815 (0.392–1.695) | 0.584 | 0.560 (0.204–1.541) | 0.262 |
N | ||||
 N0 | 1 (Reference) |  | 1 (Reference) |  |
 N1 | 1.354 (0.987–1.858) | 0.060 | 1.241 (0.892–1.725) | 0.199 |
 N2 | 1.382 (1.013–1.886) | 0.041 | 1.307 (0.951–1.795) | 0.098 |
 N3 | 1.439 (0.443–4.675) | 0.545 | 1.907 (0.587–6.197) | 0.283 |
M | ||||
 M0 | 1 (Reference) |  | 1 (Reference) |  |
 M1 | 2.358 (1.881–2.956) | < 0.001 | 2.285 (1.816–2.876) | < 0.001 |
RCc | ||||
 No | 1 (Reference) |  | 1 (Reference) |  |
 Yes | 0.433 (0.342–0.548) | < 0.001 | 0.436 (0.333–0.572) | < 0.001 |
Chemotherapy | ||||
 No/unknown | 1 (Reference) |  | Not selected |  |
 Yes | 0.605 (0.514–0.712) | < 0.001 |  |  |
Size | ||||
 ≤ 6.5 cm | 1 (Reference) |  | 1 (Reference) |  |
 >6.5 cm | 1.815 (1.510–2.182) | < 0.001 | 1.840 (1.506–2.248) | < 0.001 |
 Unknown | 1.509 (1.277–1.783) | < 0.001 | 1.510 (1.255–1.816) | < 0.001 |
LNRd | ||||
 0 | 1 (Reference) |  | 1 (Reference) |  |
 ≤ 0.0385 | 1.316 (0.578–2.993) | 0.513 | 1.195 (0.460–3.100) | 0.714 |
 >0.0385 | 2.341 (1.629–3.363) | < 0.001 | 2.797 (1.895–4.130) | < 0.001 |
 Unknown | 1.734 (1.328–2.263) | < 0.001 | 1.846 (1.359–2.509) | < 0.001 |