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Table 3 Multivariate Cox regression model analyses of overall survival and cancer specific survival in the nomogram cohort

From: Nomograms to predict individual prognosis of patients with squamous cell carcinoma of the urinary bladder

Characteristics Overall Survival (OS) Cancer Specific Survival (CSS)
HRa (95% CIb) P-value HR (95% CI) P-value
Age at diagnosis
 < 50 1(Reference)   1(Reference)  
 50–59 1.118 (0.833–1.499) 0.457 0.981 (0.725–1.328) 0.902
 60–69 1.321 (0.990–1.764) 0.059 1.161 (0.856–1.573) 0.338
 70–79 1.434 (1.089–1.888) 0.010 1.310 (0.981–1.750) 0.067
 80–89 1.935 (1.458–2.568) < 0.001 1.703 (1.263–2.297) < 0.001
 90–100 2.181 (1.473–3.228) < 0.001 2.115 (1.388–3.222) < 0.001
Marital status
 Married 1 (Reference)   1 (Reference)  
 Single 1.364 (1.176–1.583) < 0.001 1.364 (1.16–1.604) < 0.001
 Unknown 1.338 (0.956–1.872) 0.090 1.325 (0.916–1.915) 0.135
Race
 Black 1 (Reference)   Not selected  
 White 1.007 (0.819–1.238) 0.946   
 Other 0.811 (0.545–1.207) 0.302   
Sex
 Female 1 (Reference)   1 (Reference)  
 Male 0.828 (0.719–0.953) 0.009 0.790 (0.677–0.922) 0.003
Grade
 I 1 (Reference)   Not selected  
 II 1.112 (0.904–1.368) 0.314   
 III 0.772 (0.652–0.914) 0.003   
 IV 0.995 (0.879–1.125) 0.932   
T
 T1 1 (Reference)   1(Reference)  
 T2 1.394 (1.117–1.741) 0.003 1.304 (1.020–1.665) 0.034
 T3 1.660 (1.265–2.177) < 0.001 1.685 (1.251–2.270) 0.001
 T4 2.234 (1.726–2.892) < 0.001 2.104 (1.589–2.786) < 0.001
 Ta 0.475 (0.174–1.299) 0.147 0.500 (0.157–1.593) 0.241
 Tis 0.815 (0.392–1.695) 0.584 0.560 (0.204–1.541) 0.262
N
 N0 1 (Reference)   1 (Reference)  
 N1 1.354 (0.987–1.858) 0.060 1.241 (0.892–1.725) 0.199
 N2 1.382 (1.013–1.886) 0.041 1.307 (0.951–1.795) 0.098
 N3 1.439 (0.443–4.675) 0.545 1.907 (0.587–6.197) 0.283
M
 M0 1 (Reference)   1 (Reference)  
 M1 2.358 (1.881–2.956) < 0.001 2.285 (1.816–2.876) < 0.001
RCc
 No 1 (Reference)   1 (Reference)  
 Yes 0.433 (0.342–0.548) < 0.001 0.436 (0.333–0.572) < 0.001
Chemotherapy
 No/unknown 1 (Reference)   Not selected  
 Yes 0.605 (0.514–0.712) < 0.001   
Size
 ≤ 6.5 cm 1 (Reference)   1 (Reference)  
 >6.5 cm 1.815 (1.510–2.182) < 0.001 1.840 (1.506–2.248) < 0.001
 Unknown 1.509 (1.277–1.783) < 0.001 1.510 (1.255–1.816) < 0.001
LNRd
 0 1 (Reference)   1 (Reference)  
 ≤ 0.0385 1.316 (0.578–2.993) 0.513 1.195 (0.460–3.100) 0.714
 >0.0385 2.341 (1.629–3.363) < 0.001 2.797 (1.895–4.130) < 0.001
 Unknown 1.734 (1.328–2.263) < 0.001 1.846 (1.359–2.509) < 0.001
  1. aHR Hazard ratio
  2. bCI Confidence interval
  3. cRC Radical cystectomy
  4. dLNR Lymph node ratio