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Table 1 Tumor characteristics and invadodopodia formationa of tested cell lines

From: TIMP-2 secreted by monocyte-like cells is a potent suppressor of invadopodia formation in pancreatic cancer cells

Cell line

Tumor entity

Source of tumour cells

Invadopodia formation

PaTu8902

PDAC

Primary tumor

yes

CFPAC-1

PDAC

Liver metastasis

yes

MiaPaCa-2

PDAC

Primary tumor

inconsistent

CAPAN-2

PDAC

Primary tumor

inconsistent

Panc-1

PDAC

Primary tumor

inconsistent

CAPAN-1

PDAC

Liver metastasis

no

PaTu8988-T

PDAC

Liver metastasis

no

PaTu8988-S

PDAC

Liver metastasis

no

Colo357

PDAC

Lymph node metastasis

no

AsPC1

PDAC

Ascites

no

MDA-MB-231b

Breast cancer

Pleural effusion

yes

  1. PDAC Pancreatic Ductal Adenocarcinoma
  2. aActive invadopodia formation was defined as cortactin puncta corresponding with black dots on the gelatin
  3. bMDA-MB-231 cells are well known for producing robust invadopodia formation and were used as a positive control