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Table 1 Study characteristics of included studies

From: Association of hormone replacement therapy with mortality in colorectal cancer survivor: a systematic review and meta-analysis

StudyStudy periodCountryAgeNumber of participantsStageGradeHRT TypeHRT recencyCRC death/HRT userAll-cause death /HRT userMean follow-up year
Prospective cohort
 Arem et al. (2015) [13]1995–2011USA50–71205330.5% localized, 31.3% regional or distant, 38.2% unknown12.0% well-differentiated, 57.5% moderate-differentiated, 0.9% undifferentiated, 29,6% unknownE, E + PCurrent, formerCurrent (98/670), former (36/201)Current (214/670), former (87/201)7.7
 Chan et al. (2006) [14]1976–2004USA62.2–65.7a83422.3% stage I, 26.1% stage II, 25.5% stage III, 15.6% stage IV, 10.5% unknown22.3% stage I, 26.1% stage II, 25.5% stage III, 15.6% stage IV, 10.5% unknownE, E + PCurrent, formerCurrent (64/235), former (83/229)Current (87/235), former (103/229)5–10
 Mandelson et al. (2003) [15]1980–1998USA50–79699NRNRE, E + PCurrentCurrent (18/103)Current (37/103)5.33
 Slattery et al. (1999) [16]1991–1998USA55–7980135.4% local, 53.2% regional, 11.4% distantNRE, E + PCurrent to stop less than 5 yearsCurrent to stop less than 5 years (NR/186)Current to stop less than 5 years (46/186)4.0
Retrospective cohort
 Ji et al. (2018) [17]2006–2015Sweden45–69562623.7% stage I, 27.8% stage II, 36.2% stage III, 12.3% stage IVNRE, E + PCurrentCurrent (NR/1109)Current (246/1109)5.4
StudyVariables adjustedExposure assessmentMortality ascertainmentb        
Prospective cohort
 Arem et al. (2015) [13]Years from questionnaire to diagnosis, BMI, marital status, smoking status, diabetes, physical activity, cancer stage, tumor grade, and receipt of chemotherapy, radiation, and surgeryQuestionnaireSocial Security Administration Death Master File and the National Death Index Plus        
 Chan et al. (2006) [14]Age at diagnosis, year of diagnosis, cancer site (colon, rectum, or unknown), BMI, aspirin use at diagnosis, smoking status, postdiagnosis physical activity, cancer stage, tumor grade, and receipt of chemotherapyQuestionnaireNational Death Index and physician reviewer        
 Mandelson et al. (2003) [15]Age at diagnosis; year of diagnosis; and cancer stageGroup Health Cooperative computerized pharmacy databaseWestern Washington SEER registry        
 Slattery et al. (1999) [16]Age at diagnosis, study center, BMI, and cancer stageIn-person interviewLocal tumor registries        
Retrospective cohort
 Ji et al. (2018) [17]Age at diagnosis; year of diagnosis, country of birth (Sweden, European countries and others), highest educational level, family history of CRC, comorbidities with chronic ischemic heart disease, type 2 diabetes, chronic obstructive pulmonary disease and hypertension; and cancer stageSwedish Prescribed Drug RegisterCause of Death Register        
  1. aThis study provided median age of postmenopausal participants. bCauses of death and their corresponding International Classification of Diseases and Related Health Problem, 9th and 10th version (ICD-9 and ICD-10) codes were death due to colorectal cancer (ICD-9153, 154, and 159.0; and ICD-10 C18–C20, and C26), and death due to all the causes (ICD-9001–999 and ICD-10 A00–Z99). HRT hormone replacement therapy, CRC colorectal cancer, E estrogen therapy, E + P combined estrogen progesterone therapy, NR not reported, BMI body mass index, SEER Surveillance, Epidemiology, and End Results Program