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Table 6 Multivariate analysis of the cumulative incidence of cancer events and competing mortality

From: Causes of death in patients with locally advanced head and neck cancer treated with radiotherapy and systemic therapy

 

Cancer events

Competing events

Covariate

HR

95% CI

p-value

HR

95% CI

p-value

Age

0.99

0.97–1.01

0.6

1.03

0.1–1.08

0.06

Sex

 Male vs Female

0.59

0.28–1.22

0.15

1.74

0.55–5.47

0.34

Comorbidity

 0–1 vs 2–6

0.86

0.48–1.55

0.62

3.42

1.46–7.97

0.01

ECOG

 0 vs 1–2

1.50

1.01–2.21

0.04

0.94

0.42–2.1

0.88

Stage

 III vs IV

1.73

1.14–2.63

0.01

0.63

0.25–1.33

0.20

Technique

 3DRT vs IMRT

0.61

0.34–1.09

0.1

0.76

0.25–2.30

0.63

Treatment

 CRT, RTCTX,ICT

1.08

0.76–1.53

0.68

1.16

0.66–2.06

0.60

Acute Mucositis

 0–2 vs 3–5

0.80

0.51–123

0.3

1.63

0.72–3.68

0.24

Acute PL toxicity

  0–2 vs 3–5

1.33

0.79–2.23

0.29

1.24

0.44–3.48

0.69

Chronic PL toxicity

 0–2 vs 3–5

0.89

0.57–1.38

0.60

0.78

0.36–1.72

0.54

  1. CI confidence interval, ECOG Eastern Cooperative Oncology Group, HR hazard ratio