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Table 5 Five year cumulative incidence of cancer and competitive mortality

From: Causes of death in patients with locally advanced head and neck cancer treated with radiotherapy and systemic therapy

Covariate

Cancer events

Competitive mortality

Cumulative Incidence

95% CI

p

Cumulative Incidence

95% CI

p

Sex

 Male

40.4

34.0–46.7

0.3

11.0

7.7–16.0

0.48

 Female

33.3

13.6–54.6

 

14.0

4.3–29.2

 

Comorbidity

 0–1

35.50

29.2–41.8

0.29

7.0

4.6–11.7

0.01

 2–6

33.30

20.7–46.4

 

24.6

17.9–46.2

 

ECOG

 0

30.20

23.2–37.4

0.01

9.30

5.5–14.6

0.35

 1–2

42.30

33.0–51.3

 

11.0

6.2–17.5

 

Stage

 III

24.4

16.6–33.1

0.01

11.7

6.4–18.9

0.21

 IV

41.8

34.1–49.1

 

9.0

5.4–13.9

 

Location

 Oral Cavity

41.0

17.8–63.5

0.35

10.0

2.5–23.9

0.99

 Oropharynx

39.0

27.8–49.8

 

13.0

6.6–21.9

 

 Larynx

37.0

28.2–45.5

 

11.0

6.3–17.4

 

 Hypopharynx

52.0

32.6–68.6

 

10.0

3.2–22.2

 

Treatment

 ICT

52.00

36.3–65.6

0.01

3.92

0.7–12.0

0.63

 CRT

27.10

20.3–34.3

 

10.1

6.6–16.6

 

 RTCTX

41.60

30.0–52.7

 

12.4

6.0–21.1

 

RT Technique

 3DRT

40.0

33.0–46.4

0.8

12.5

8.4–17.4

0.4

 IMRT

58.0

17.9–84.0

 

8.0

2.7–17.8

 

RT Fractionation

 Conventional

37.0

29.1–45.4

0.63

12.0

7.2–17.8

0.66

 Others

43.0

33.7–52.5

 

12.0

6.5–18.6

 

Acute PL toxicity

 0–1

28.1

15.9–41.6

0.5

9.0

2.7–19.3

0.34

  ≥ 2

36.6

30.2–42.8

 

10.3

6.8–14.7

 

Acute mucosa toxicity

 0–2

36.4

28.6–44.2

0.66

7.4

3.9–12.5

0.07

 3–5

34.0

25.8–42.3

 

13.0

7.9–19.5

 

Chronic PL toxicity

 0–1

35.8

32.6–47.5

0.93

11.3

8.3–18.2

0.47

  ≥ 2

34.1

27.8–49.5

 

8.0

3.5–15.3

 
  1. CI confidence interval, DFS disease-free survival, ECOG Eastern Cooperative Oncology Group, HR Hazard ratio, OS Overall Survival, PL Pharyngolarynx