Comparative items | Data type | Heterogeneity test | Test of Association | Publication bias | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MMSE and protein marker | Items | Q value | d.f. | I-squared | Tau-squared | P Value | Heterogeneity | Effect model | Pooled WMD | WMD 95% CI | Pooled SMD | SMD 95% CI | Z value | P value | Statistical significance | ||
Preoperative cognitive function | Preoperative MMSE | Continuous | 55.09 | 12 | 78.2% | 0.1449 | 0.000 | Yes | Random | -0.040 | [−0.288, 0.208] | − 0.038 | [− 0.274, 0.198] | 0.31 | 0.753 | No | No |
Postoperative cognitive function evaluation | MMSE 6 h | Continuous | 199.17 | 10 | 95.0% | 1.0826 | 0.000 | Yes | Random | −1.922 | [−2.571, − 1.274] | −1.391 | [− 2.024, −0.757] | 4.30 | 0.000 | Yes | No |
MMSE 24 h | Continuous | 216.54 | 13 | 94.0% | 0.7859 | 0.000 | Yes | Random | −1.504 | [−2.253, −0.755] | − 1.106 | [− 1.588, − 0.624] | 4.50 | 0.000 | Yes | No | |
MMSE 3d | Continuous | 140.36 | 10 | 92.9% | 0.6585 | 0.000 | Yes | Random | −1.376 | [−2.044, −0.708] | − 1.065 | [− 1.564, − 0.566] | 4.19 | 0.000 | Yes | No | |
MMSE 7d | Continuous | 16.75 | 9 | 46.3% | NA | 0.053 | No | fixed | −0.371 | [−0.493, − 0.249] | −0.422 | [− 0.549, − 0.295] | 6.52 | 0.000 | Yes | No | |
Protein marker S100β | S100β 1d | Continuous | 67.94 | 12 | 82.3% | 0.2024 | 0.000 | Yes | Random | 0.018 | [0.016, 0.020] | 0.746 | [0.475, 1.017] | 5.39 | 0.000 | Yes | No |