Table 3 Correlation of ARID1a, BRG1 and BRM1 expression with molecular tumor data
| Â | Â | ARID1a expression | Â | BRG1 expression | Â | BRM expression | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Negative | Positive | Â | Negative | Positive | Â | Negative | Positive | Â | ||||||||
No. | % | No. | % | p value | No. | % | No. | % | p value | No. | % | No. | % | p value | ||
MET amplification | none | 45 | 9.9% | 408 | 90.1% | 0.642 | 18 | 4.0% | 433 | 96.0% | 1.00 | 44 | 9.6% | 414 | 90.4% | 0.002 |
amplified | 2 | 14.3% | 12 | 85.7% | 0 | 0.0% | 15 | 100.0% | 6 | 40.0% | 9 | 60.0% | ||||
C-myc amplification | none | 44 | 10.5% | 376 | 89.5% | 0.099 | 17 | 4.0% | 406 | 96.0% | 0.709 | 45 | 10.5% | 384 | 89.5% | 0.491 |
amplified | 2 | 3.4% | 56 | 96.6% | 1 | 1.8% | 56 | 98.2% | 4 | 6.9% | 54 | 93.1% | ||||
KRAS amplification | none | 39 | 9.7% | 364 | 90.3% | 0.839 | 17 | 4.2% | 384 | 95.8% | 0.548 | 46 | 11.3% | 360 | 88.7% | 0.037 |
amplified | 7 | 8.0% | 80 | 92.0% | 2 | 2.2% | 87 | 97.8% | 4 | 4.3% | 90 | 95.7% | ||||
GATA6 amplification | none | 44 | 10.4% | 381 | 89.6% | 0.070 | 19 | 4.5% | 405 | 95.5% | 0.240 | 45 | 10.5% | 384 | 89.5% | 0.631 |
amplified | 1 | 2.1% | 46 | 97.9% | 0 | 0.0% | 47 | 100.0% | 6 | 12.2% | 43 | Â | ||||
PIK3CA amplification | none | 44 | 10.7% | 368 | 89.3% | 1.000 | 15 | 3.6% | 400 | 96.4% | 0.236 | 47 | 11.2% | 371 | 88.8% | 0.417 |
amplified | 2 | 8.3% | 22 | 91.7% | 2 | 8.3% | 22 | 91.7% | 3 | 12.5% | 21 | 87.5% | ||||
ERBB2 amplification | none | 33 | 10.7% | 275 | 89.3% | 0.596 | 13 | 4.2% | 297 | 95.8% | 0.381 | 35 | 11.3% | 276 | 88.7% | 1.000 |
amplified | 3 | 7.0% | 40 | 93.0% | 0 | 0.0% | 43 | 100% | 4 | 9.5% | 38 | 90.5% | ||||
TP53 mutation | negative | 16 | 10.5% | 136 | 89.5% | 0.594 | 7 | 4.6% | 146 | 95.4% | 0.410 | 19 | 12.8% | 130 | 87.2% | 0.304 |
mutated | 19 | 8.9% | 195 | 91.1% | 6 | 2.9% | 200 | 97.1% | 20 | 9.2% | 197 | 90.8 | ||||