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Table 1 Correlation of ARID1a, BRG1 and BRM expression for the entire patients cohort

From: Loss of the SWI/SNF-ATPase subunit members SMARCF1 (ARID1A), SMARCA2 (BRM), SMARCA4 (BRG1) and SMARCB1 (INI1) in oesophageal adenocarcinoma

 

ARID1a expression

BRG1 expression

BRM expression

 

Negative

Positive

p-value

 

Negative

Positive

p-value

 

Negative

Positive

p-value

Total

560*

58

10.4%

502

89.6%

 

563*

19

3.4%

544

96.6%

 

578*

57

9.9%

521

90.1%

 

Sex

 Female

65

7

10.8%

58

89.2%

0.831

67

1

1.5%

66

98.5%

0.715

68

11

16.2%

57

83.8%

0.080

 Male

495

51

10.3%

444

89.7%

496

18

3.6%

478

96.4%

510

46

9.0%

464

91.0%

Age group

 <65

185

17

9.2%

168

90.8%

0.399

186

4

2.2%

182

97.8%

0.239

191

20

10.5%

171

89.5%

0.199

 >65

174

19

10.9%

155

89.1%

170

9

5.3%

161

94.7%

173

20

11.6%

153

88.4%

pT stage

 1

81

9

11.1%

72

88.9%

0.657

79

3

3.8%

76

96.2%

0.448

86

8

9.3%

78

90.7%

0.981

 2

72

8

11.1%

64

88.9%

73

1

1.4%

72

98.6%

72

6

8.3%

66

91.7%

 3

385

41

10.6%

344

89.4%

388

13

3.4%

375

96.6%

398

41

10.3%

357

89.7%

 4

19

0

0%

19

100%

20

2

10%

18

90.0%

20

2

10.0%

18

90.0%

Lymph node metastasis

 pN0

217

31

14.3%

186

85.7%

0.086

216

8

3.7%

208

96.3%

0.952

227

20

8.8%

207

91.2%

0.651

 pN 1

196

13

6.6%

183

93.4%

197

6

3%

191

97.0%

194

23

11.9%

171

88.1%

 pN 2

74

7

9.5%

67

90.5%

74

2

2.7%

72

97.3%

79

6

7.6%

73

92.4%

 pN 3

71

7

9.9%

64

90.1%

74

3

4.1%

71

95.9%

76

8

10.5%

68

89.5%

Grading

 G1

4

1

25%

3

75%

0.186

5

0

0%

5

100%

< 0.001

6

0

0%

6

100%

0.119

 G2

218

16

7.3%

202

92.7%

217

3

1.4%

214

98.6%

221

20

9.0%

201

91.0%

 

 G3

167

22

13.2%

145

86,8%

172

10

5.8%

162

94.2%

177

24

13.6%

153

86.4%

 
  1. *Total numbers of patients do not add due to missing clinical data in some cases