Table 2 Geometric mean (95% confidence interval) normalized abundances of acylcarnitines in Cases and Controls
| Â | Cases | Controls | |||
|---|---|---|---|---|---|
Aylcarnitines (normalized abundance) | Low Risk | High Risk without Progression | High Risk with progression | Metastatic | Healthy |
L.Carnitine (C0) | 22,341 (17389–28,703) | 24,578 (20774–29,078) | 22,514 (17877–28,355) | 23,767 (21161–26,695) | 25,038 (19910–31,487) |
Total Carnitines | 87,554 (71512–107,194) | 95,564 (80237–113,817) | 88,145 (78007–99,600) | 106,009 (77213–145,545) | 77,690 (65760–91,784) |
Total Carnitines (norm.) | 2.81 (1.89–4.18) | 2.80 (2.04–3.84) | 2.80 (1.89–4.14) | 3.36 (2.26–5.00) | 2.07 (1.68–2.55) |
Short Chain Acylcarnitines (C2-C5 norm.) | 1.24 (0.84–1.83) | 1.12 (0.82–1.52) | 1.19 (0.82–1.72) | 1.65 (1.08–2.51) | 0.93 (0.76–1.13) |
Medium Chain Acylcarnitines (C6-C12 norm.) | 0.87 (0.55–1.39) | 1.00 (0.65–1.54) | 0.93 (0.55–1.57) | 0.93 (0.52–1.64) | 0.52 (0.34–0.80) |
Long Chain Acylcarnitines (C14-C16 norm.) | 0.70 (0.48–1.03) | 0.67 (0.53–0.84) | 0.65 (0.45–0.95) | 0.71 (0.55–0.93) | 0.56 (0.45–0.69) |
Acylcarnitine (C2 norm.) | 0.83 (0.55–1.25) | 0.75 (0.52–1.06) | 0.79 (0.50–1.23) | 0.95 (0.66–1.37) | 0.59 (0.48–0.72) |
Propionylcarnitine (C3 norm.) | 0.09 (0.06–0.14) | 0.07 (0.05–0.10) | 0.09 (0.07–0.12) | 0.10 (0.07–0.14) | 0.09 (0.06–0.13) |
Butyrylcarnitine (C4 norm.) | 0.11 (0.06–0.18) | 0.10 (0.07–0.13) | 0.12 (0.09–0.15) | 0.14 (0.09–0.23) | 0.11 (0.06–0.18) |
Methylmalonylcarnitine (C4 Methyl norm.) | 0.004 (0.003–0.005) | 0.003 (0.002–0.004) | 0.004 (0.003–0.006) | 0.005 (0.003–0.008) | 0.003 (0.002–0.004) |
Isovalerylcarnitine (C5 norm.) | 0.12 (0.08–0.18) | 0.11 (0.08–0.14) | 0.12 (0.09–0.15) | 0.18 (0.06–0.52) | 0.09 (0.07–0.13) |
Hexanoylcarnitine (C6 norm.) | 0.03 (0.02–0.05) | 0.03 (0.02–0.05) | 0.04 (0.02–0.06) | 0.04 (0.02–0.07) | 0.02 (0.01–0.03) |
L.Octanoylcarnitine (C8 norm.) | 0.17 (0.12–0.26) | 0.22 (0.14–0.34) a | 0.20 (0.12–0.32) | 0.20 (0.11–0.37) | 0.11 (0.07–0.17) |
Decanoylcarnitine (C10 norm.) | 0.41 (0.26–0.66) | 0.50 (0.32–0.78) a | 0.45 (0.26–0.77) | 0.44 (0.25–0.80) | 0.25 (0.15–0.40) |
Dodecanoylcarnitine (C12 norm.) | 0.23 (0.13–0.39) | 0.23 (0.15–0.35) a | 0.23 (0.13–0.40) | 0.22 (0.12–0.37) a | 0.13 (0.09–0.19) |
Tetradecanoylcarnitine (C14 norm.) | 0.13 (0.08–0.211) | 0.12 (0.09–0.17) | 0.12 (0.07–0.19) | 0.13 (0.09–0.20) | 0.09 (0.07–0.11) |
L.Palmitoylcarnitine (C16 norm.) | 0.56 (0.44–0.74) | 0.53 (0.43–0.67) | 0.53 (0.37–0.75) | 0.57 (0.44–0.74) | 0.46 (0.37–0.57) |