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Table 2 Geometric mean (95% confidence interval) normalized abundances of acylcarnitines in Cases and Controls

From: Preoperative plasma fatty acid metabolites inform risk of prostate cancer progression and may be used for personalized patient stratification

 CasesControls
Aylcarnitines (normalized abundance)Low RiskHigh Risk without ProgressionHigh Risk with progressionMetastaticHealthy
L.Carnitine (C0)22,341 (17389–28,703)24,578 (20774–29,078)22,514 (17877–28,355)23,767 (21161–26,695)25,038 (19910–31,487)
Total Carnitines87,554 (71512–107,194)95,564 (80237–113,817)88,145 (78007–99,600)106,009 (77213–145,545)77,690 (65760–91,784)
Total Carnitines (norm.)2.81 (1.89–4.18)2.80 (2.04–3.84)2.80 (1.89–4.14)3.36 (2.26–5.00)2.07 (1.68–2.55)
Short Chain Acylcarnitines (C2-C5 norm.)1.24 (0.84–1.83)1.12 (0.82–1.52)1.19 (0.82–1.72)1.65 (1.08–2.51)0.93 (0.76–1.13)
Medium Chain Acylcarnitines (C6-C12 norm.)0.87 (0.55–1.39)1.00 (0.65–1.54)0.93 (0.55–1.57)0.93 (0.52–1.64)0.52 (0.34–0.80)
Long Chain Acylcarnitines (C14-C16 norm.)0.70 (0.48–1.03)0.67 (0.53–0.84)0.65 (0.45–0.95)0.71 (0.55–0.93)0.56 (0.45–0.69)
Acylcarnitine (C2 norm.)0.83 (0.55–1.25)0.75 (0.52–1.06)0.79 (0.50–1.23)0.95 (0.66–1.37)0.59 (0.48–0.72)
Propionylcarnitine (C3 norm.)0.09 (0.06–0.14)0.07 (0.05–0.10)0.09 (0.07–0.12)0.10 (0.07–0.14)0.09 (0.06–0.13)
Butyrylcarnitine (C4 norm.)0.11 (0.06–0.18)0.10 (0.07–0.13)0.12 (0.09–0.15)0.14 (0.09–0.23)0.11 (0.06–0.18)
Methylmalonylcarnitine (C4 Methyl norm.)0.004 (0.003–0.005)0.003 (0.002–0.004)0.004 (0.003–0.006)0.005 (0.003–0.008)0.003 (0.002–0.004)
Isovalerylcarnitine (C5 norm.)0.12 (0.08–0.18)0.11 (0.08–0.14)0.12 (0.09–0.15)0.18 (0.06–0.52)0.09 (0.07–0.13)
Hexanoylcarnitine (C6 norm.)0.03 (0.02–0.05)0.03 (0.02–0.05)0.04 (0.02–0.06)0.04 (0.02–0.07)0.02 (0.01–0.03)
L.Octanoylcarnitine (C8 norm.)0.17 (0.12–0.26)0.22 (0.14–0.34) a0.20 (0.12–0.32)0.20 (0.11–0.37)0.11 (0.07–0.17)
Decanoylcarnitine (C10 norm.)0.41 (0.26–0.66)0.50 (0.32–0.78) a0.45 (0.26–0.77)0.44 (0.25–0.80)0.25 (0.15–0.40)
Dodecanoylcarnitine (C12 norm.)0.23 (0.13–0.39)0.23 (0.15–0.35) a0.23 (0.13–0.40)0.22 (0.12–0.37) a0.13 (0.09–0.19)
Tetradecanoylcarnitine (C14 norm.)0.13 (0.08–0.211)0.12 (0.09–0.17)0.12 (0.07–0.19)0.13 (0.09–0.20)0.09 (0.07–0.11)
L.Palmitoylcarnitine (C16 norm.)0.56 (0.44–0.74)0.53 (0.43–0.67)0.53 (0.37–0.75)0.57 (0.44–0.74)0.46 (0.37–0.57)
  1. Acylcarnitines abundance is normalized by data mean intensities and by C0 (L.Carnitine) abundance (norm.). a OPLS-DA models selected based on multivariate statistical analysis (Controls vs Specific Cases)