Fig. 6

Association between annotated metabolites and disease progression and analysis of gene expression data. PSA progression-free survival calculated by the Kaplan Meier method for (a) suberic acid and (b) indoleacetic acid and lymph node progression-free survival for indoleacetic acid is represented in (c). Groups are defined by median-cut off of normalized abundances (low abundance, blue solid line) vs high abundance (red dotted line). P-value was estimated with log-rank test. IDO1 expression data of primary and androgen ablation resistant metastasis are shown from GSE6752 (d) and GSE6919 (e-f). ACADM expression data in the same set of samples are displayed in (g-h-i). Fold change (FC) is calculated versus the normal or primary tumor samples and p-value (P) for significance between two groups estimated by t-test. For statistical details see Methods section