Fig. 3

The TCR signaling pathway plays an opposite role in the OS of 6 cancer types. a TCR signal-triggering module. TCR signaling activation is initiated by the recognition of cognate peptide–MHC molecules, and then LCK phosphorylates the ITAMs (including the CD3γ chain (CD3G), the CD3δ chain (CD3D), the CD3ε chains (CD3E), and the ζ-chains (CD247)). Activated ITAMs provide docking sites for the SH2 domains of ZAP-70, which is phosphorylated by Lck, allowing propagation of downstream signaling events. b HR of 11 PIGs involved in the TCR signaling pathway in 6 cancer types. All HRs were > 1 (risk factor) in LGG but<1 (protective factor) in 5 cancer types (BRCA, CESC, HNSC, LUAD, and SARC)