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Table 3 Extensive evaluations of associations between the clinicopathological variables and the UGT2B28-rs2132039 variant types (i.e. the dependent variable, TT = 0, Non-TT = 1) using univariate and multivariate logistic regression analysis

From: Ages of hepatocellular carcinoma occurrence and life expectancy are associated with a UGT2B28 genomic variation

Characteristic

Odds ratio

95%CI

P-value

Univariate analysis

 Gender, male

0.824

0.509–1.334

0.431

 Age at diagnosis, years

1.021

1.006–1.036

0.005*

 Tumor size, cm

0.981

0.932–1.032

0.449

 Tumor number

1.084

0.886–1.328

0.432

 Capsule

1.094

0.695–1.721

0.699

 Tumor grade

0.940

0.698–1.266

0.685

 Macrovascular invasion

0.842

0.440–1.610

0.603

 Microvascular invasion

0.760

0.493–1.170

0.212

 Cirrhosis

1.072

0.713–1.613

0.737

 Ascites

3.223

1.264–8.215

0.014*

 Alcoholism

0.845

0.533–1.340

0.475

 HBV

0.710

0.458–1.101

0.126

 HCV

1.839

1.148–2.945

0.011*

 HBV + HCV

1.291

0.644–2.588

0.471

 NBNC

0.848

0.479–1.502

0.572

 Prothrombin time, second

0.938

0.811–1.084

0.385

 AST, U/L

1.002

0.999–1.005

0.246

 ALT, U/L

1.003

1.000–1.005

0.095

 Bilirubin, mg/dL

0.960

0.808–1.142

0.646

 Albumin, g/dL

0.820

0.572–1.175

0.279

 Creatinine, mg/dL

0.976

0.790–1.206

0.823

 Alpha-fetoprotein, ng/mL

1.000

1.000–1.000

0.377

 Recurrent

1.208

0.806–1.811

0.359

 Recurrent time, month

0.995

0.988–1.001

0.113

 Metastasis

0.692

0.415–1.156

0.160

 Metastatic time, month

0.998

0.991–1.004

0.435

 Death

0.767

0.416–1.414

0.395

 Survival time, month

0.998

0.992–1.005

0.632

Multivariate analysis

 Age, years

1.016

1.001–1.032

0.037*

 Ascites

3.505

1.358–9.048

0.010*

 HCV

1.646

0.999–2.713

0.050

  1. Abbreviations: CI Confidence interval, HBV Hepatitis B virus carrier, HCV Hepatitis C virus carrier, HBV + HCV Co-infection of hepatitis B virus and hepatitis C virus, NBNC Non-hepatitis B/hepatitis C virus carrier, AST Aspartate aminotransferase, ALT Alanine aminotransferase
  2. *P < 0.05 were indicated as bold face with an asterisk