Table 2 NEK1, NEK3, and NEK5 expression levels according to semiquantitative and quantitative IHC analysis in benign and malignant thyroid nodules and nucleus and cytoplasm
From: Expression of the NEK family in normal and cancer tissue: an immunohistochemical study
Semiquantitative IHC | Quantitative IHC | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein expression | Analyzed groups | p-value | Sensitivity (%) | Specificity (%) | PPV* (%) | NPV* (%) | Protein expression | Analyzed groups | p-value | Sensitivity (%) | Specificity (%) | PPV* (%) | NPV* (%) |
Nek1 Cytoplasmic | Malignant vs Benign | <0.0001 | 94 | 47 | 81 | 74 | Nek1 | Malignant vs Benign | 0.0006 | 61 | 64 | 79 | 43 |
Nek1 | N.S | 56 | 53 | 75 | 32 | ||||||||
Nuclear | |||||||||||||
Nek3 Cytoplasmic | Malignant vs Benign | N.S | 98 | 0.7 | 73 | 60 | Nek3 | Malignant vs Benign | <0.0001 | 78 | 80 | 91 | 60 |
Nek5 Cytoplasmic | Malignant vs Benign | N.S | 98 | 0.3 | 75 | 50 | Nek5 | Malignant vs Benign | N.S | 77 | 50 | 82 | 42 |
Nek5 | 0.0144 | 26 | 50 | 58 | 20 | ||||||||
Nuclear | |||||||||||||