Inclusion Criteria | Exclusion Criteria |
---|---|
• Adult men and women at least 30 years of age • Meet criteria for overweight or obesity via body mass index (BMI) or waist size • Underwent colonoscopy screening within the past 10 years • History of pathology-confirmed precancerous polyp of the colon or rectum; OR colorectal cancer survivor who has completed treatment with adequate maintenance of bowel length (hemicolectomy or low anterior resection) and normalized bowel habits • English-speaking and reside in the greater Houston/outlying areas and/or willing to travel for study-related visits at MD Anderson • Ability to complete web-based dietary assessments twice per week • Willingness to provide stool samples and undergo venipuncture • Willingness to consume/avoid beans as instructed during the 16 weeks from randomization | • Antibiotic use in the past month and unable/unwilling to be deferred to a later recruitment date • Current smoker • Heavy drinker (defined as more than 14 drinks per week) • Currently taking exclusionary prescription medications (including cytokines, immunosuppressive agents, chemopreventive drugs, bile acid sequestrants/selective cholesterol absorption inhibitors) • Regularly taking anti-flatulence medications, probiotics and/or fiber supplements and unable/unwilling to discontinue for the purpose of the study • Major dietary restrictions relevant to the intervention • Total or near total colectomy, greater than 10 cm of small bowel resection • Hereditary colorectal cancer syndromes • Pregnant or lactating or planning to become pregnant |