Fig. 1

HEYL expression in colorectal cancer in the context of metastasis. a Kaplan-Meier estimates of overall survival (OS) of colorectal cancer patients within the TCGA stratified by HEYL expression within the tumors. High expression is defined as median or higher and low expression as below-median. Median survival is marked by a dashed line. The absolute numbers of patients at risk (n) are depicted below each figure. b HEYL mRNA expression levels at primary compared to metastatic lesions in a cohort of 83 unresectable colorectal cancer patients prior to chemotherapy [33]. Expression levels were measured as signal intensity within the Affymetrix Human Genome U133 Plus 2.0 Array. Both box plots show mean (+ symbol), median (line), interquartile range (box) range (whiskers) and outsider of the 1.5 interquartile range (dots). The total number of patients per group is depicted on the left side of each box