Fig. 6

Pathway analyses in serum metabolites. a Metabolite Set Enrichment Analysis of serum metabolism. Significantly enriched pathways are annotated in the pathway network. The circle size denotes significance of the pathway, and lines denote at least 25% shared metabolites in the pathways. b Ingenuity pathway analysis (IPA) bar chart showing the top 5 functions enriched in the dataset. c IPA pathway network showing the metabolites connected to four microRNAs found to be involved in tamoxifen resistance. Metabolites in green are downregulated in carbohydrate-fed patients, while metabolites in red are upregulated. MicroRNAs are colored purple. d IPA Function plot showing metabolites involved in organismal growth. Orange arrows indicate activation, while blue arrows indicate inhibition