Fig. 3

Correlation between serum metabolic profile and serum insulin, insulin C-peptide, and IGFBP3. Samples from carbohydrate-fed patients are shown in red, while samples from fasting patients are shown in blue. Metabolites are colored according to their variable importance in projection (VIP) score and labeled when VIP≥1. a Measured insulin vs. predicted insulin levels based on metabolic profile (cross-validated measurements). b Metabolites versus regression coefficient for insulin. Increased S-glucose, S-lactate, and decreased S-Leucine are important to prediction of serum insulin from the metabolic profile. c Measured insulin C peptide vs. predicted insulin C-peptide levels. d Regression weight plot showing metabolites versus the regression coefficient for insulin C-peptide. Increased S-Glucose, S-Lactate, and decreased S-Leucine are important to prediction of serum insulin C-peptide from the metabolic profile. e Measured Insulin Growth Factor Binding Protein 3 (IGFBP3) vs. predicted IGFBP3 based on metabolic profile. f Regression weight plot showing metabolites versus the regression coefficient for IGFBP3. Increased S-Acetone, S-Glycoproteins, and S-Leucine are important to prediction of serum IGFBP3 from the metabolic profile