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Table 2 Recommended dose constraints for non-lung organs. 5-fraction and 8-fraction constraints based on RTOG 0813 protocol [16], SABR-COMET protocol [17], and Timmerman et al [18]. Constraints for other fractionation schemes are derived using BED3

From: Assessment of precision irradiation in early non-small cell lung cancer and interstitial lung disease (ASPIRE-ILD): study protocol for a phase II trial

Structure Number of Fractions
5 10 15
Spinal Cord (contoured as spinal canal) Max 30 Gy 34.5 Gy 39.5 Gy
< 0.25 cc 22.5 Gy 29 Gy 33 Gy
< 1.2 cc 13.5 Gy 17 Gy 19 Gy
Esophagus Max 35 Gy 43.5 Gy 50.5 Gy
< 5 cc 27.5 Gy 35.5 Gy 41 Gy
Ipsilateral Brachial Plexus Max 32 Gy 42.5 Gy 49 Gy
<  3 cc 30 Gy 39.5 Gy 45.5 Gy
Heart Max 38 Gy 50 Gy 58.5 Gy
15 cc 32 Gy 42.5 Gy 49 Gy
Great Vessels Max 53 Gy 71.5 Gya 84 Gya
10 cc 47 Gy 63.5 Gy 74.5 Gya
Trachea and Ipsilateral Bronchus Max 38 Gy 43.5 Gy 50.5 Gy
4 cc 18 Gy 23 Gy 26 Gy
Skin Max 32 Gy 42.5 Gy 49 Gy
10 cc 30 Gy 39.5 Gy 45.5 Gy
Stomach Max 32 Gy 43.5 Gy 50.5 Gy
10 cc 28 Gy 37 Gy 42.5 Gy
Liver At least 700 cc < 21 Gy < 23.5 Gy < 26.5 Gy
Chest Wall Keep as low as reasonably achievable, do not compromise PTV, respect PTV conformality parameters
  1. aAlthough calculated tolerance dose is much higher, seek to limit any point of the organ to 110% of prescription dose. Non-adjacent wall must always be limited to 105% (see below)