Assessment of precision irradiation in early non-small cell lung cancer and interstitial lung disease (ASPIRE-ILD): study protocol for a phase II trial

Table 2 Recommended dose constraints for non-lung organs. 5-fraction and 8-fraction constraints based on RTOG 0813 protocol [16], SABR-COMET protocol [17], and Timmerman et al [18]. Constraints for other fractionation schemes are derived using BED₃

Structure		Number of Fractions
Structure		5	10	15
Spinal Cord (contoured as spinal canal)	Max	30 Gy	34.5 Gy	39.5 Gy
	< 0.25 cc	22.5 Gy	29 Gy	33 Gy
	< 1.2 cc	13.5 Gy	17 Gy	19 Gy
Esophagus	Max	35 Gy	43.5 Gy	50.5 Gy
Esophagus	< 5 cc	27.5 Gy	35.5 Gy	41 Gy
Ipsilateral Brachial Plexus	Max	32 Gy	42.5 Gy	49 Gy
Ipsilateral Brachial Plexus	< 3 cc	30 Gy	39.5 Gy	45.5 Gy
Heart	Max	38 Gy	50 Gy	58.5 Gy
Heart	15 cc	32 Gy	42.5 Gy	49 Gy
Great Vessels	Max	53 Gy	71.5 Gy^a	84 Gy^a
Great Vessels	10 cc	47 Gy	63.5 Gy	74.5 Gy^a
Trachea and Ipsilateral Bronchus	Max	38 Gy	43.5 Gy	50.5 Gy
Trachea and Ipsilateral Bronchus	4 cc	18 Gy	23 Gy	26 Gy
Skin	Max	32 Gy	42.5 Gy	49 Gy
Skin	10 cc	30 Gy	39.5 Gy	45.5 Gy
Stomach	Max	32 Gy	43.5 Gy	50.5 Gy
Stomach	10 cc	28 Gy	37 Gy	42.5 Gy
Liver	At least 700 cc	< 21 Gy	< 23.5 Gy	< 26.5 Gy
Chest Wall	Keep as low as reasonably achievable, do not compromise PTV, respect PTV conformality parameters

^aAlthough calculated tolerance dose is much higher, seek to limit any point of the organ to 110% of prescription dose. Non-adjacent wall must always be limited to 105% (see below)

ISSN: 1471-2407