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Table 3 Univariate analysis for Overall Survival

From: Prognostic impact of platinum sensitivity in ovarian carcinoma patients with brain metastasis

Characteristic

HR (95% CI)

p value

Agea

1.02 (0.96–1.08)

0.493

ECOG performance statusa

2.52 (1.25–5.09)

0.010

Family History of Breast or Ovarian Cancer

 No

1

0.593

 Yes

0.73 (0.23–2.30)

 

Histology

 HGCS

1

0.747

 Other histologies

0.81 (0.22–3.00)

 

Time-point of CNS metastasis

 Platinum sensitive

1

0.049

 Platinum resistant

2.89 (1.01–8.31)

 

Previous lines before diagnosis of BMa

1.57 (1.12–2.19)

0.008

Disease progression outside CNS

 No

1

0.236

 Yes

0.52 (0.18–1.53)

 

Number of metastasisa

1.06 (0.99–1.13)

0.104

Metastasis sizea

0.83 (0.49–1.39)

0.473

Time from diagnosisa

1.01 (1.00–1.01)

0.200

Platinum free intervala

0.99 (0.93–1.05)

0.747

  1. ECOG Eastern Cooperative Oncology Group, HGSC High grade serous carcinoma, CNS Central nervous system
  2. aevaluated as continuous variables