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Table 4 List of 20 significant ‘GO Biological process’ that were obtained using miRNA-targeted genes in Pancreatic Cancer

From: Comparison of tumour and serum specific microRNA changes dissecting their role in pancreatic ductal adenocarcinoma: a meta-analysis

Sl.noTermAdjusted P-valueGenes
1PI3K-Akt signaling pathway_Homo sapiens_hsa041512.96E-09PRKAA1;PHLPP1;IRS1;ITGB4;LAMA3;PTEN;PIK3CD;PIK3R1;THBS1;IGF1R;GNG2;CCND2;AKT3;EIF4EBP1;JAK2;IL6R;EIF4B;MCL1;PDGFRB;IFNAR2;LAMB3;ITGA3;HGF;ITGA2;FN1;LAMB1;PPP2R5C;VEGFA;IL6;COL1A2;CREB1;COL4A2;CCNE2;COL4A1;CDK2;DDIT4;COL4A5;IL7R;TLR4;FGFR3;EPHA2;BCL2L1
2AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049334.42E-08SMAD4;VCAM1;SMAD3;SERPINE1;FN1;PIK3CD;PIK3R1;F3;TGFBR1;VEGFA;IL6;COL1A2;PLCB4;COL4A2;COL4A1;AKT3;BAX;COL4A5;CCL2;JAK2
3Focal adhesion_Homo sapiens_hsa045109.82E-08SHC1;ITGB4;LAMA3;PTEN;PIK3CD;PIK3R1;THBS1;IGF1R;PAK1;CCND2;AKT3;FLNA;PDGFRB;LAMB3;CAV2;ITGA3;HGF;ITGA2;FN1;LAMB1;VEGFA;COL1A2;COL4A2;COL4A1;ZYX;COL4A5;CTNNB1;PPP1R12B
4p53 signaling pathway_Homo sapiens_hsa041151.09E-06RRM2;EI24;SERPINE1;PTEN;THBS1;SERPINB5;CCNB2;TP53I3;CCND2;CCNE2;CDK2;CHEK1;BAX;PMAIP1;BID
5FoxO signaling pathway_Homo sapiens_hsa040683.69E-06PRKAA1;SMAD4;GABARAPL1;SMAD3;IRS1;PLK2;BNIP3;PTEN;PIK3CD;PIK3R1;STK4;TGFBR1;IGF1R;CCNB2;IL6;CCND2;AKT3;CDK2;TNFSF10;IL7R
6MicroRNAs in cancer_Homo sapiens_hsa052062.19E-05DNMT1;SLC45A3;BMPR2;IRS1;SHC1;PTEN;PTGS2;SLC7A1;THBS1;CCND2;STMN1;HMOX1;TIMP3;E2F3;MCL1;PDGFRB;KIF23;SERPINB5;CDC25A;VEGFA;CDC25B;ZEB2;CCNE2;DDIT4;FSCN1;VIM;ZFPM2;FGFR3;RECK;EZH2
7HIF-1 signaling pathway_Homo sapiens_hsa040661.21E-04PFKFB3;TFRC;SERPINE1;PIK3CD;PIK3R1;IGF1R;VEGFA;HK1;IL6;AKT3;EIF4EBP1;HMOX1;TIMP1;IL6R;TLR4
8Proteoglycans in cancer_Homo sapiens_hsa052051.37E-04CAV2;HGF;ITGA2;WNT5A;FN1;GAB1;ITPR1;PLAUR;PIK3CD;PIK3R1;THBS1;VEGFA;IGF1R;PAK1;AKT3;TIMP3;CTNNB1;FLNA;HPSE;PPP1R12B;TLR4;EIF4B
9ECM-receptor interaction_Homo sapiens_hsa045127.42E-04COL1A2;LAMB3;COL4A2;ITGA3;COL4A1;ITGB4;ITGA2;LAMA3;FN1;COL4A5;LAMB1;THBS1
10mTOR signaling pathway_Homo sapiens_hsa041509.57E-04PRKAA1;IRS1;AKT3;DDIT4;EIF4EBP1;PTEN;PIK3CD;PIK3R1;EIF4B;VEGFA
11Ras signaling pathway_Homo sapiens_hsa040141.58E-03PDGFRB;RAB5C;SHC1;HGF;GAB1;PLA2G4A;PIK3CD;PIK3R1;RASAL2;STK4;VEGFA;RASGRP3;IGF1R;PAK1;GNG2;AKT3;REL;ABL2;FGFR3;EPHA2;BCL2L1
12Pancreatic cancer_Homo sapiens_hsa052121.81E-03SMAD4;SMAD3;AKT3;TGFA;PIK3CD;E2F3;PIK3R1;TGFBR1;VEGFA;BCL2L1
13TNF signaling pathway_Homo sapiens_hsa046682.26E-03VCAM1;JAG1;LIF;TNFAIP3;PIK3CD;PIK3R1;CFLAR;PTGS2;SOCS3;IL6;CREB1;AKT3;CCL2
14TGF-beta signaling pathway_Homo sapiens_hsa043509.04E-03SMAD1;SMAD4;BMPR2;SMAD3;SMURF2;ID1;THBS1;TGFBR1;ACVR2A;SMAD7
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.60E-02LYN;VCAM1;BLNK;TNFAIP3;CFLAR;TNFRSF11A;PTGS2;TLR4;MALT1;BCL2L1
16Transcriptional misregulation in cancer_Homo sapiens_hsa052021.85E-02SMAD1;MEF2C;SLC45A3;TAF15;RUNX2;IGF1R;IL6;CCND2;NR4A3;WT1;SIN3A;REL;ERG;RUNX1T1;BCL2L1
17Chemokine signaling pathway_Homo sapiens_hsa040622.43E-02LYN;CXCL9;SHC1;PIK3CD;CXCR4;ARRB1;PIK3R1;ARRB2;CXCL13;PAK1;GNG2;PLCB4;AKT3;CCL2;JAK2
18Prolactin signaling pathway_Homo sapiens_hsa049172.59E-02SOCS3;CCND2;SHC1;AKT3;PIK3CD;TNFRSF11A;PIK3R1;JAK2
19Jak-STAT signaling pathway_Homo sapiens_hsa046303.02E-02IFNAR2;LIF;PIK3CD;PIK3R1;SOCS3;IL6;CCND2;AKT3;IL7R;JAK2;IL6R;BCL2L1;MCL1
20Insulin resistance_Homo sapiens_hsa049313.41E-02SOCS3;PRKAA1;IL6;CREB1;IRS1;GFPT2;AKT3;PTEN;PIK3CD;PIK3R1