Table 1 Specific characteristics of colon adenocarcinoma and GISTs
| Â | Colon adenocarcinoma | GIST (1) | GIST (2) | GIST (others) |
|---|---|---|---|---|
Location | Ascending colon | 10–50 cm from the Treitz’s ligament | 10–50 cm from the Treitz’s ligament | 10–50 cm from the Treitz’s ligament |
Size (cm) | 5 × 3 × 3 | 3.7 × 2.2 × 2.8 | 2.5 × 2.5 × 2.3 | 0.5 × 0.5 × 0.6 |
Grade | moderately differentiated | low risk | low risk | very low risk |
IHC | NF1 pan-stained, wt-p53, CK818+ | NF1+, CD117+, Dog-1+, CD34+, S-100-, E-cad-, CK818-, SMA+, Caldesmon+, β-catenin+, E-cad-, Ki-67+ (4%) | NF1+, CD117+, Dog-1+, CD34+, S-100-, E-cad-, CK818-, SMA+, desmin- | CD117+, Dog-1+, S-100-, SMA+, desmin- |
MLH1+, PMS2+, MSH2+, MSH6+ | ||||
WES | KRAS, PIK3CA, APC, SMAD4 | NF1, MSS, TMB (low) | NF1, MSS, TMB (low) | – |
APOB, ATPAF2, CACNA1H, COL6A3, DECR2, DLG2, DOK3, DYNC1I1, HCN1, KIAA1841, KIF6, KLRG1, MYOD1, NEFH, OR10C1, OR8A1, PTPN7, RGS18, RHOBTB1, SPATS2L, STAC, SYNPO2L, TAS1R2, USH2A, VEPH1 |