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Table 1 Description of scoring summary used for the histology evaluation of bladder from mice

From: Detection of carcinogen-induced bladder cancer by fluorocoxib A

 

Score/Type

Description

Inflammation

0

no presence of inflammatory cells

1

low presence of inflammatory cells

2

moderate presence of inflammatory cells

3

high presence of inflammatory cells

N, L, P, M

Type of inflammatory cells - Neutrophils, Lymphocytes, Plasma cells, Macrophages

Hyperplasia

0

no hyperplasia (less than 2 cells in urothelial layer) present

1

low hyperplasia (between 3 and 5 cells in urothelial layer) present

2

severe hyperplasia (more than 5 cells in urothelial layer) present

D, F, M

Diffuse, Focal, Multi-focal hyperplasia

Carcinoma in situ (CIS)

0

no CIS present

Yes

CIS present

Carcinomaa

0

no carcinoma present

Yes

carcinoma present

  1. Notes: aIncluding adenocarcinoma, squamous cell carcinoma and transitional cell carcinoma