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Table 4 Multivariable Cox regression analyses predicting cancer-specific survival

From: Effect of lymph node dissection on stage-specific survival in patients with upper urinary tract urothelial carcinoma treated with nephroureterectomy

 

All stage

T1

T2

T3

T4

Multivariable a

HR (95% CI)

Multivariable b

HR (95% CI)

Multivariable b

HR (95% CI)

Multivariable b

HR (95% CI)

Multivariable b

HR (95% CI)

LND status

 No LND

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

 LND

0.81 (0.73–0.95)**

0.84 (0.56–1.25)

0.87 (0.61–1.24)

0.83 (0.73–0.98)*

0.64 (0.47–0.88)**

LND extent

 No LND

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

 Limited LND

0.86 (0.75–0.96)*

1.02 (0.65–1.59)

1.02 (0.69–1.51)

0.92 (0.78–1.16)

0.61 (0.43–0.87)**

 Extended LND

0.73 (0.61–0.88)**

0.56 (0.29–1.08)

0.65 (0.38–1.12)

0.74 (0.58–0.95)*

0.70 (0.47–0.96)*

Lymph node stage

 pN0

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

 pNx

1.32 (1.13–1.53)***

1.29 (0.85–1.98)

1.19 (0.83–1.72)

1.22 (1.01–1.49)*

1.97 (1.31–2.97)**

 pN1–3

2.49 (2.06–3.01)***

3.40 (1.61–7.18)**

3.35 (1.87–5.99)***

2.32 (1.81–2.98)***

2.55 (1.64–3.98)***

  1. *P < 0.05, **P < 0.01, ***P < 0.001. a Adjusted to age, gender, race, tumor location, laterality, tumor size, tumor stage, tumor grade, chemotherapy and year of surgery. b Adjusted to age, gender, race, tumor location, laterality, tumor size, tumor grade, chemotherapy and year of surgery. HR hazard ratio, 95% CI 95% confidence interval, LND lymph node dissection