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Table 3 Multivariable Cox regression analyses predicting overall survival

From: Effect of lymph node dissection on stage-specific survival in patients with upper urinary tract urothelial carcinoma treated with nephroureterectomy

 All stagesT1T2T3T4
Multivariable a
HR (95% CI)
Multivariable b
HR (95% CI)
Multivariable b
HR (95% CI)
Multivariable b
HR (95% CI)
Multivariable b
HR (95% CI)
LND status
 No LND1.00 (Ref.)1.00 (Ref.)1.00 (Ref.)1.00 (Ref.)1.00 (Ref.)
 LND0.87 (0.80–0.95)**0.98 (0.80–1.19)0.85 (0.70–1.04)0.88 (0.78–0.99)*0.74 (0.59–0.94)*
LND extent
 No LND1.00 (Ref.)1.00 (Ref.)1.00 (Ref.)1.00 (Ref.)1.00 (Ref.)
 Limited LND0.90 (0.81–0.99)*0.98 (0.78–1.25)0.87 (0.69–1.11)0.93 (0.81–1.07)0.73 (0.57–0.94)**
 Extended LND0.83 (0.74–0.94)**0.97 (0.73–1.30)0.82 (0.61–1.09)0.80 (0.68–0.95)*0.77 (0.57–0.99)*
Lymph node stage
 pN01.00 (Ref.)1.00 (Ref.)1.00 (Ref.)1.00 (Ref.)1.00 (Ref.)
 pNx1.19 (1.08–1.30)***1.05 (0.86–1.29)1.20 (0.98–1.48)1.15 (1.01–1.31)*1.59 (1.20–2.11)**
 pN1–32.20 (1.93–2.50)***2.13 (1.33–3.41)**2.33 (1.60–3.40)***2.00 (1.68–2.39)***2.26 (1.65–3.10)***
  1. *P < 0.05, **P < 0.01, ***P < 0.001. a Adjusted to age, gender, race, tumor location, laterality, tumor size, tumor stage, tumor grade, chemotherapy and year of surgery. b Adjusted to age, gender, race, tumor location, laterality, tumor size, tumor grade, chemotherapy and year of surgery. HR hazard ratio, 95% CI 95% confidence interval, LND lymph node dissection