Skip to main content
Fig. 5 | BMC Cancer

Fig. 5

From: Remodeling of hepatic stellate cells orchestrated the stroma-derived oxaliplatin-resistance through CCN3 paracrine in hepatocellular carcinoma

Fig. 5

CCN3 induce the remodeling of HSC with elevation of cytokines relating to HCC malignancy. The significantly changed cytokines expression profiles were found in CCN3 treated LX2 by cytokines array (a). RANTES, TGFβ and TIMP-2 were selected for immunoblotting, and NFκB was proved as one of the control signaling pathway (b). The reduced migration and inhibited proliferation of LX2 were proved in the CM from NFκB inhibitor EVP4593 treated MHCC97H (c)

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us