Fig. 2From: Remodeling of hepatic stellate cells orchestrated the stroma-derived oxaliplatin-resistance through CCN3 paracrine in hepatocellular carcinomaExpression of CCN3 is upregulated in oxaliplatin-resistant HCC. The increased resistance to oxaliplatin was in MHCC97H-OXA and Hep3B-OXA over that of parental cells (a). PCR (b), ELISA (c), Immunoblotting (d) and Immunofluorescence (e) revealed that the expression of CCN3 in MHCC97H-OXA cells was significantly higher than that of parental cells. IHC revealed CCN3 expression was significantly up-regulated in oxaliplatin-resistant HCC subcutaneous tissue (f)Back to article page