Impact of early chimerism status on clinical outcome in children with acute lymphoblastic leukaemia after haematopoietic stem cell transplantation

Lejman, Monika; Zaucha-Prażmo, Agnieszka; Zawitkowska, Joanna; Mroczkowska, Aleksandra; Grabowski, Dominik; Kowalczyk, Jerzy R.; Drabko, Katarzyna

doi:10.1186/s12885-019-6360-3

Table 2 Characteristics of factors influencing on the early chimerism status

From: Impact of early chimerism status on clinical outcome in children with acute lymphoblastic leukaemia after haematopoietic stem cell transplantation

Transplant variables	Donor chimerism level (median %)
Transplant variables	+ 7 day	p value	+ 14 day	p value	+ 21 day	p value	+ 28 day	p value
Underlying diseases
B ALL n = 31	58	p = 0.9	100	p = 0.3	100	p = 0.79	100	p = 0.58
T ALL n = 25	63	p = 0.9	95	p = 0.3	100	p = 0.79	100	p = 0.58
Age of patient
< median (8.67 years) n = 28	58	p = 0.98	95	p = 0.66	100	p = 0.73	100	p = 0.86
> median (8.67 years) n = 28	65	p = 0.98	99	p = 0.66	100	p = 0.73	100	p = 0.86
Patient gender
Male n = 38	61	p = 0.99	94	p = 0.15	100	p = 0.68	100	p = 0.7
Female n = 18	62	p = 0.99	100	p = 0.15	100	p = 0.68	100	p = 0.7
Donor type
Matched related n = 25	49	p = 0.06	90	p = 0.02	100		100
Matched unrelated n = 28	68		100		100	p = 0.01	100	p = 0.02
Mismatched related n = 3	80		100		100		100
Donor gender
Male n = 31	77	p = 0.003	100	p = 0.041	100	p = 0.56	100	p = 0.80
Female n = 25	46	p = 0.003	89	p = 0.041	100	p = 0.56	100	p = 0.80
Stem cell source
Bone marrow n = 47	60	p = 0.64	96	p = 0.20	100	p = 0.32	100	p = 0.19
Peripheral blood n = 9	63	p = 0.64	100	p = 0.20	100	p = 0.32	100	p = 0.19
Conditioning regimen
Radiation-based n = 41	60	p = 0.33	96	p = 0.40	100	p = 0.40	100	p = 0.43
Busulfan-based n = 2	74		80		85		91
Reduced toxicity n = 13	67		100		100		100
Serotherapy (ATG)
YES n = 28	49	p = 0.05	94	p = 0.11	100	p = 0.016	100	p = 0.023
NO n = 28	68	p = 0.05	100	p = 0.11	100	p = 0.016	100	p = 0.023
Number of CD34+ cells (median 4,47)
< 4,47 × 10⁶ n = 35	58	p = 0.41	94	p = 0.036	100	p = 0.08	100	p = 0.19
> 4,47 × 10⁶ n = 21	67	p = 0.41	100	p = 0.036	100	p = 0.08	100	p = 0.19
Patients
without event n = 48	62	p = 0.98	68	p = 0.48	100	p = 0.88	100	p = 0.56
with relapse n = 5	64		97		100		100
with TRM no relapse n = 3	65		81		100		100

B ALL B-cell acute lymphoblastic leukaemia, T ALL T-cell acute lymphoblastic leukaemia, ATG Anti-thymocyte globulin, TRM Transplant related mortality, p = 0.05 this result is on the border of the statistical significance

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ISSN: 1471-2407

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