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Table 2 Association of clinicopathologic characteristics and proteins related to glycolytic metabolism with pathological complete response (pCR) – univariate and multivariate analysis

From: CAIX is a predictor of pathological complete response and is associated with higher survival in locally advanced breast cancer submitted to neoadjuvant chemotherapy

CharacteristicsCategoriesUnivariate analysisMultivariate analysis
Odds Ratio (95% CI)pOdds Ratio (95% CI)p
Age (years)≥ 50Ref Ref 
<  502.683 (1.171–6.149)0.0202.631 (0.856–8.087)0.091
Histological typeInvasive NSTRef Ref 
Others0.371 (0.083–1.650)0.1930.723(0.114–4.605)0.731
TNM - TT1 + T2Ref  
T3 + T41.323 (0.545–3.211)0.536 
TNM - NN0 + N1Ref Ref 
N2 + N33.436 (1.147–10.293)0.0270.182 (0.038–0.887)0.035
SubtypeLuminal ARef Ref 
Luminal B/HER2 -1.000 (0.192–5.197)1.0000.458 (0.049–4.311)0.494
Luminal B/HER2 +3.529 (0.716–17.404)0.1212.029 (0.067–61.316)0.684
HER23.333 (0.567–19.593)0.1830.647 (0.016–26.726)0.818
 Triple-negative2.400 (0.436–13.202)0.3140.183 (0.011–2.926)0.230
Estrogen receptorNegativeRef Ref 
Positive0.354 (0.164–0.767)0.0080.254 (0.041–1.552)0.138
Progesterone receptorNegativeRef  
Positive1.185 (0.554–2.534)0.662 
HER2 overexpressionNegativeRef Ref 
Positive2.584 (1.197–5.580)0.0160.922 (0.057–14.873)0.954
Ki 67<  14%Ref  
≥ 14%2.447 (0.547–10.940)0.242 
Tubule formation≥ 10%Ref  
<  10%1.118 (0.308–4.063)0.866 
Mitotic rate1 + 2Ref Ref 
30.324 (0.149–0.703)0.0044.899 (1.439–16.673)0.011
Nuclear gradeG1 + G2Ref Ref 
G31.802 (0.734–4.426)0.1990.598 (0.140–2.546)0.487
Nottingham histological gradeG1 + G2Ref  
G31.651 (0.765–3.564)0.201 
NecrosisAbsentRef Ref 
Present2.071 (0.964–4.449)0.0621.186 (0.3335–4.192)0.792
Inflammatory infiltrateAbsentRef Ref 
Present2.258 (0.747–6.829)0.1490.740 (0.188–2.916)0.667
Lymphatic invasionAbsentRef  
Present0.538 (0.177–1.638)0.275 
MCT1NegativeRef  
Positive0.436 (0.054–3.509)0.436 
MCT4NegativeRef  
Positive0.736 (0.158–3.418)0.696 
CD147NegativeRef  
Positive1.747 (0.176–17.387)0.634 
GLUT1NegativeRef Ref 
Positive2.558 (1.074–6.091)0.0343.166 (0.882–11.360)0.077
CAIXNegativeRef Ref 
Positive5.494 (1.689–17.866)0.0056.221 (1.148–33.706)0.034
  1. NST No Special Type, Ref Reference. Significant values are shown in bold