Characteristics | Categories | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|---|
Odds Ratio (95% CI) | p | Odds Ratio (95% CI) | p | ||
Age (years) | ≥ 50 | Ref | Ref | ||
< 50 | 2.683 (1.171–6.149) | 0.020 | 2.631 (0.856–8.087) | 0.091 | |
Histological type | Invasive NST | Ref | Ref | ||
Others | 0.371 (0.083–1.650) | 0.193 | 0.723(0.114–4.605) | 0.731 | |
TNM - T | T1 + T2 | Ref | – | ||
T3 + T4 | 1.323 (0.545–3.211) | 0.536 | – | ||
TNM - N | N0 + N1 | Ref | Ref | ||
N2 + N3 | 3.436 (1.147–10.293) | 0.027 | 0.182 (0.038–0.887) | 0.035 | |
Subtype | Luminal A | Ref | Ref | ||
Luminal B/HER2 - | 1.000 (0.192–5.197) | 1.000 | 0.458 (0.049–4.311) | 0.494 | |
Luminal B/HER2 + | 3.529 (0.716–17.404) | 0.121 | 2.029 (0.067–61.316) | 0.684 | |
HER2 | 3.333 (0.567–19.593) | 0.183 | 0.647 (0.016–26.726) | 0.818 | |
Triple-negative | 2.400 (0.436–13.202) | 0.314 | 0.183 (0.011–2.926) | 0.230 | |
Estrogen receptor | Negative | Ref | Ref | ||
Positive | 0.354 (0.164–0.767) | 0.008 | 0.254 (0.041–1.552) | 0.138 | |
Progesterone receptor | Negative | Ref | – | ||
Positive | 1.185 (0.554–2.534) | 0.662 | – | ||
HER2 overexpression | Negative | Ref | Ref | ||
Positive | 2.584 (1.197–5.580) | 0.016 | 0.922 (0.057–14.873) | 0.954 | |
Ki 67 | < 14% | Ref | – | ||
≥ 14% | 2.447 (0.547–10.940) | 0.242 | – | ||
Tubule formation | ≥ 10% | Ref | – | ||
< 10% | 1.118 (0.308–4.063) | 0.866 | – | ||
Mitotic rate | 1 + 2 | Ref | Ref | ||
3 | 0.324 (0.149–0.703) | 0.004 | 4.899 (1.439–16.673) | 0.011 | |
Nuclear grade | G1 + G2 | Ref | Ref | ||
G3 | 1.802 (0.734–4.426) | 0.199 | 0.598 (0.140–2.546) | 0.487 | |
Nottingham histological grade | G1 + G2 | Ref | – | ||
G3 | 1.651 (0.765–3.564) | 0.201 | – | ||
Necrosis | Absent | Ref | Ref | ||
Present | 2.071 (0.964–4.449) | 0.062 | 1.186 (0.3335–4.192) | 0.792 | |
Inflammatory infiltrate | Absent | Ref | Ref | ||
Present | 2.258 (0.747–6.829) | 0.149 | 0.740 (0.188–2.916) | 0.667 | |
Lymphatic invasion | Absent | Ref | – | ||
Present | 0.538 (0.177–1.638) | 0.275 | – | ||
MCT1 | Negative | Ref | – | ||
Positive | 0.436 (0.054–3.509) | 0.436 | – | ||
MCT4 | Negative | Ref | – | ||
Positive | 0.736 (0.158–3.418) | 0.696 | – | ||
CD147 | Negative | Ref | – | ||
Positive | 1.747 (0.176–17.387) | 0.634 | – | ||
GLUT1 | Negative | Ref | Ref | ||
Positive | 2.558 (1.074–6.091) | 0.034 | 3.166 (0.882–11.360) | 0.077 | |
CAIX | Negative | Ref | Ref | ||
Positive | 5.494 (1.689–17.866) | 0.005 | 6.221 (1.148–33.706) | 0.034 |