Skip to main content

Table 2 Association of clinicopathologic characteristics and proteins related to glycolytic metabolism with pathological complete response (pCR) – univariate and multivariate analysis

From: CAIX is a predictor of pathological complete response and is associated with higher survival in locally advanced breast cancer submitted to neoadjuvant chemotherapy

Characteristics

Categories

Univariate analysis

Multivariate analysis

Odds Ratio (95% CI)

p

Odds Ratio (95% CI)

p

Age (years)

≥ 50

Ref

 

Ref

 

<  50

2.683 (1.171–6.149)

0.020

2.631 (0.856–8.087)

0.091

Histological type

Invasive NST

Ref

 

Ref

 

Others

0.371 (0.083–1.650)

0.193

0.723(0.114–4.605)

0.731

TNM - T

T1 + T2

Ref

 

 

T3 + T4

1.323 (0.545–3.211)

0.536

 

TNM - N

N0 + N1

Ref

 

Ref

 

N2 + N3

3.436 (1.147–10.293)

0.027

0.182 (0.038–0.887)

0.035

Subtype

Luminal A

Ref

 

Ref

 

Luminal B/HER2 -

1.000 (0.192–5.197)

1.000

0.458 (0.049–4.311)

0.494

Luminal B/HER2 +

3.529 (0.716–17.404)

0.121

2.029 (0.067–61.316)

0.684

HER2

3.333 (0.567–19.593)

0.183

0.647 (0.016–26.726)

0.818

 

Triple-negative

2.400 (0.436–13.202)

0.314

0.183 (0.011–2.926)

0.230

Estrogen receptor

Negative

Ref

 

Ref

 

Positive

0.354 (0.164–0.767)

0.008

0.254 (0.041–1.552)

0.138

Progesterone receptor

Negative

Ref

 

 

Positive

1.185 (0.554–2.534)

0.662

 

HER2 overexpression

Negative

Ref

 

Ref

 

Positive

2.584 (1.197–5.580)

0.016

0.922 (0.057–14.873)

0.954

Ki 67

<  14%

Ref

 

 

≥ 14%

2.447 (0.547–10.940)

0.242

 

Tubule formation

≥ 10%

Ref

 

 

<  10%

1.118 (0.308–4.063)

0.866

 

Mitotic rate

1 + 2

Ref

 

Ref

 

3

0.324 (0.149–0.703)

0.004

4.899 (1.439–16.673)

0.011

Nuclear grade

G1 + G2

Ref

 

Ref

 

G3

1.802 (0.734–4.426)

0.199

0.598 (0.140–2.546)

0.487

Nottingham histological grade

G1 + G2

Ref

 

 

G3

1.651 (0.765–3.564)

0.201

 

Necrosis

Absent

Ref

 

Ref

 

Present

2.071 (0.964–4.449)

0.062

1.186 (0.3335–4.192)

0.792

Inflammatory infiltrate

Absent

Ref

 

Ref

 

Present

2.258 (0.747–6.829)

0.149

0.740 (0.188–2.916)

0.667

Lymphatic invasion

Absent

Ref

 

 

Present

0.538 (0.177–1.638)

0.275

 

MCT1

Negative

Ref

 

 

Positive

0.436 (0.054–3.509)

0.436

 

MCT4

Negative

Ref

 

 

Positive

0.736 (0.158–3.418)

0.696

 

CD147

Negative

Ref

 

 

Positive

1.747 (0.176–17.387)

0.634

 

GLUT1

Negative

Ref

 

Ref

 

Positive

2.558 (1.074–6.091)

0.034

3.166 (0.882–11.360)

0.077

CAIX

Negative

Ref

 

Ref

 

Positive

5.494 (1.689–17.866)

0.005

6.221 (1.148–33.706)

0.034

  1. NST No Special Type, Ref Reference. Significant values are shown in bold