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Table 2 Symptom clusters of chemotherapy-induced peripheral neuropathy over time

From: Redefining chemotherapy-induced peripheral neuropathy through symptom cluster analysis and patient-reported outcome data over time

Symptom ClusterSymptomsT1T2T3T4T5T6T7T8T9T10
The sensory neuropathy symptom clusterTingling feet
Tingling hands
Numbness in feet
Numbness in hands   
Burning pain in hands        
Burning pain in feet        
Cramps in hands        
Cramps in feet       
Vomiting         
Nausea         
Loadings0.47–0.880.51–0.760.54–0.870.70–0.850.77–0.820.55–0.840.50–0.900.65–0.840.66–0.840.53–0.81
Internal consistencyα = 0.86α = 0.86α = 0.86α = 0.91α = 0.88α = 0.82α = 0.93α = 0.87α = 0.82α = 0.87
 Variance explained (%)11.6212.3712.429.569.577.877.419.017.2915.96
The motor-sensory neuropathy symptom clusterManipulating small objects
Holding pen
Opening jars or bottles       
Difficulty walking because feet dropped downwards       
Climbing stairs        
Cramps in hands         
Distinguishing hot-cold      
Burning pain in hands        
Burning pain in feet         
Standing/walking from difficulty feeling the ground under feet         
Dizzyness         
Loadings0.49–0.780.65–0.650.46–0.770.50–0.780.49–0.790.81–0.820.55–0.710.44–0.790.81–0.860.65–0.84
Internal consistencyα = 0.58α = 0.62α = 0.81α = 0.77α = 0.78α = 0.86α = 0.76α = 0.87α = 0.85α = 0.64
 Variance explained (%)7.465.368.966.907.589.368.4810.106.335.39
The sensorimotor neuropathy symptom clusterStanding/walking from difficulty feeling the ground under feet
Difficulty remembering         
Difficulty with concentration         
Difficulty walking because feet dropped downwards  
Distinguishing hot-cold        
Climbing stairs     
Burning pain in hands        
Burning pain in feet        
Cramps in hands     
Cramps in feet       
Nausea         
Weakness in legs         
Constipation         
Needs resting         
Tired         
Having trouble sleeping         
Pain         
Opening jars or bottles         
Loadings0.80–0.910.45–0.770.37–0.690.54–0.720.78–0.840.52–0.720.22–0.820.22–0.700.39–0.810.63–0.88
Internal consistencyα = 0.82α = 0.72α = 0.80α = 0.86α = 0.81α = 0.81α = 0.70α = 0.86α = 0.84α = 0.88
 Variance explained (%)7.587.195.7912.096.198.545.2913.6110.6111.01
The autonomic neuropathy symptom clusterBlurred vision
Climbing stairs        
Dizzyness     
Difficulty with concentration      
Difficulty remembering       
Pain        
Needs resting         
Having trouble sleeping         
Constipation         
Shortness of breath         
Opening jars or bottles         
Difficulty hearing     
Burning pain in feet        
Burning pain in hands         
Standing/walking from difficulty feeling the ground under feet         
Difficulty walking because feet dropped downwards         
Loadings0.86–0.970.42–0.680.69–0.810.47–0.870.44–0.700.41–0.770.47–0.610.40–0.720.57–0.681.00–1.00
Internal consistencyα = 0.90α = 0.78α = 0.57α = 0.63α = 0.59α = 0.58α = 0.78α = 0.67α = 0.66α = 1.00
 Variance explained (%)7.5610.495.665.435.585.726.966.516.565.80
  1. Bold is used to indicate core symptom(s)