Redefining chemotherapy-induced peripheral neuropathy through symptom cluster analysis and patient-reported outcome data over time

Wang, Mian; Cheng, Hui Lin; Lopez, Violeta; Sundar, Raghav; Yorke, Janelle; Molassiotis, Alex

doi:10.1186/s12885-019-6352-3

Table 2 Symptom clusters of chemotherapy-induced peripheral neuropathy over time

From: Redefining chemotherapy-induced peripheral neuropathy through symptom cluster analysis and patient-reported outcome data over time

Symptom Cluster	Symptoms	T1	T2	T3	T4	T5	T6	T7	T8	T9	T10
The sensory neuropathy symptom cluster	Tingling feet	•	•	•	•	•	•	•	•	•	•
	Tingling hands	•	•	•	•	•	•	•	•	•	•
	Numbness in feet	•	•	•	•	•	•	•	•	•	•
	Numbness in hands			•	•	•	•	•	•		•
	Burning pain in hands	•	•
	Burning pain in feet	•	•
	Cramps in hands	•	•
	Cramps in feet		•	•							•
	Vomiting										•
	Nausea										•
	Loadings	0.47–0.88	0.51–0.76	0.54–0.87	0.70–0.85	0.77–0.82	0.55–0.84	0.50–0.90	0.65–0.84	0.66–0.84	0.53–0.81
	Internal consistency	α = 0.86	α = 0.86	α = 0.86	α = 0.91	α = 0.88	α = 0.82	α = 0.93	α = 0.87	α = 0.82	α = 0.87
	Variance explained (%)	11.62	12.37	12.42	9.56	9.57	7.87	7.41	9.01	7.29	15.96
The motor-sensory neuropathy symptom cluster	Manipulating small objects	•	•	•	•	•	•	•	•	•	•
	Holding pen	•	•	•	•	•	•	•	•	•	•
	Opening jars or bottles	•			•				•
	Difficulty walking because feet dropped downwards	•		•					•
	Climbing stairs			•					•
	Cramps in hands			•
	Distinguishing hot-cold				•	•	•	•
	Burning pain in hands					•		•
	Burning pain in feet							•
	Standing/walking from difficulty feeling the ground under feet								•
	Dizzyness								•
	Loadings	0.49–0.78	0.65–0.65	0.46–0.77	0.50–0.78	0.49–0.79	0.81–0.82	0.55–0.71	0.44–0.79	0.81–0.86	0.65–0.84
	Internal consistency	α = 0.58	α = 0.62	α = 0.81	α = 0.77	α = 0.78	α = 0.86	α = 0.76	α = 0.87	α = 0.85	α = 0.64
	Variance explained (%)	7.46	5.36	8.96	6.90	7.58	9.36	8.48	10.10	6.33	5.39
The sensorimotor neuropathy symptom cluster	Standing/walking from difficulty feeling the ground under feet	•	•	•	•	•	•	•	•	•	•
	Difficulty remembering	•
	Difficulty with concentration	•
	Difficulty walking because feet dropped downwards		•		•	•	•	•	•	•	•
	Distinguishing hot-cold		•	•
	Climbing stairs		•		•		•			•	•
	Burning pain in hands			•	•
	Burning pain in feet			•	•
	Cramps in hands				•		•	•	•		•
	Cramps in feet				•		•	•
	Nausea								•
	Weakness in legs								•
	Constipation								•
	Needs resting								•
	Tired								•
	Having trouble sleeping								•
	Pain									•
	Opening jars or bottles										•
	Loadings	0.80–0.91	0.45–0.77	0.37–0.69	0.54–0.72	0.78–0.84	0.52–0.72	0.22–0.82	0.22–0.70	0.39–0.81	0.63–0.88
	Internal consistency	α = 0.82	α = 0.72	α = 0.80	α = 0.86	α = 0.81	α = 0.81	α = 0.70	α = 0.86	α = 0.84	α = 0.88
	Variance explained (%)	7.58	7.19	5.79	12.09	6.19	8.54	5.29	13.61	10.61	11.01
The autonomic neuropathy symptom cluster	Blurred vision	•	•	•	•	•	•	•	•	•	•
	Climbing stairs	•						•
	Dizzyness	•	•					•	•		•
	Difficulty with concentration		•		•				•	•
	Difficulty remembering		•						•	•
	Pain		•					•
	Needs resting		•
	Having trouble sleeping		•
	Constipation		•
	Shortness of breath		•
	Opening jars or bottles		•
	Difficulty hearing			•	•	•			•	•
	Burning pain in feet					•	•
	Burning pain in hands						•
	Standing/walking from difficulty feeling the ground under feet							•
	Difficulty walking because feet dropped downwards							•
	Loadings	0.86–0.97	0.42–0.68	0.69–0.81	0.47–0.87	0.44–0.70	0.41–0.77	0.47–0.61	0.40–0.72	0.57–0.68	1.00–1.00
	Internal consistency	α = 0.90	α = 0.78	α = 0.57	α = 0.63	α = 0.59	α = 0.58	α = 0.78	α = 0.67	α = 0.66	α = 1.00
	Variance explained (%)	7.56	10.49	5.66	5.43	5.58	5.72	6.96	6.51	6.56	5.80

Bold is used to indicate core symptom(s)

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ISSN: 1471-2407

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