Table 4 Cox regression analysis for various potential prognostic factors in overall survival
Variable | Unfavorable/ favorable characteristics | No. of Patients | Univariate (U) | Multivariate (M) | ||||
|---|---|---|---|---|---|---|---|---|
Relative risk | 95% confidential interval | P value | Relative risk | 95% confidential interval | P value | |||
Grade | 4,3 / 2,1 | 14 / 36 | 2.579 | 1.425–4.667 | 0.0017 | 2.171 | 0.956–4.931 | 0.0639 |
pT | 4,3 / 2,1 | 13 / 37 | 6.666 | 1.548–28.711 | 0.0109 | 4.222 | 0.745–23.922 | 0.1036 |
pN | 2,1 / 0 | 18 / 32 | 2.365 | 1.095–5.110 | 0.0285 | 1.366 | 0.732–1.293 | 0.5042 |
Mutation of Nrf2 | (+) / (−) | 5 / 45 | 3.015 | 1.030–8.824 | 0.0440 | 2.791 | 0.610–12.768 | 0.1859 |
SNPs of rs6721961 | CA, AA / CC | 20 / 30 | 2.139 | 1.010–4.530 | 0.0469 | 1.167 | 0.857–1.351 | 0.7341 |
Expression of Nrf2 | high / low | 24 / 26 | 8.485 | 3.102–23.210 | < 0.0001 | 6.435 | 1.964–21.087 | 0.0021 |
Mutation of Keap1 | (+) / (−) | 11 / 39 | 1.679 | 0.758–3.721 | 0.2016 | 1.122 | 0.891–1.347 | 0.8107 |