Skip to main content

Table 3 Relationship between molecules and treatment response in metastatic lesions (n = 50)

From: Nrf2 gene mutation and single nucleotide polymorphism rs6721961 of the Nrf2 promoter region in renal cell cancer

 

CR/PR/SD > 12w* (n = 26)

SD < 12w/PD* (n = 24)

p value

Mutation of Nrf2

 (+) (n = 5)

0

5

0.0142

(−) (n = 45)

26

19

SNPs at rs6721961

 C/C (n = 30)

21

9

0.0018

 C/A or A/A (n = 20)

5

15

Nrf2 expresion

 Low (n = 26)

21

5

< 0.0001

 High (n = 24)

5

19

 

Mutation of Keap1

  (+) (n = 11)

6

5

0.8783

  (−) (n = 39)

20

19

  1. CR/PR/SD > 12w* Complete response, partial response, or stable disease for > 12 weeks
  2. SD < 12w/PD* Stable disease for < 12 weeks or progressive disease
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us