Table 2 Timeline, study treatment, study visits and medical procedures

Written informed consent

X

Demographics

X

Overall medical history

X

ECOG/WHO performance status

X

X

X

X

Adverse events

X

X

X

EORTC QLQ-NMIBC24

X

X

X

SF-36 quality of life

X

X

X

Medication diary

X

X

X

Physical:

 Physical examination

X

X

X

 TURB

X

X

Haematology:

 Complete blood counts

X

X

X

 PT, APTT

X

Clinical chemistry:

 Renal function

X

X

X

 Liver function

X

X

X

 Serum glucose

X

X

X

 HbA1c

X

X

 Insulin

X

X

 IGF-1

X

X

 IGF binding protein-3

X

X

Other Investigations:

 Metformin concentration in serum

X

X

 Metformin concentration in urine

X

X

 Urinalysis

X

X

X

 Pathological review of biopsies

X

X