Whole lesion histogram analysis of apparent diffusion coefficients on MRI predicts disease-free survival in locally advanced squamous cell cervical cancer after radical chemo-radiotherapy

Table 3 Univariate and multivariate Cox regression analysis of clinical factors and ADC histogram parameters for predicting disease-free survival

Parameter	Univariate analysis	P-value	Multivariate analysis	P-value
Age (years)	1.026 (0.987–1.066)	0.194*	1.004 (0.963–1.046)	0.858
Grade
Well/moderate	1.0
Poorly	2.731 (1.242–6.005)	0.412
MTD	1.004 (0.981–1.027)	0.764
FIGO stage
IB/IIA	1.0
IIB/III/IV	1.256 (0.572–2.760)	0.570
SCC-Ag	1.004 (0.982–1.027)	0.716
Median (×10⁻³ mm²/s)	0.435 (0.037–5.075)	0.507
Max (× 10^− 3 mm²/s)	0.918 (0.613–1.373)	0.676
Mean (×10⁻³ mm²/s)	0.397 (0.032–4.968)	0.474
Min (×10⁻³ mm²/s)	0.171 (0.063–0.463)	0.001#	0.110 (0.023–0.538)	0.006#
10% (×10⁻³ mm²/s)	0.106 (0.006–1.933)	0.130*	1.803 (0.069–46.817)	0.723
90% (×10⁻³ mm²/s)	0.793 (0.287–2.193)	0.655
Kurtosis	0.950 (0.821–0.099)	0.489
Skewness	0.657 (0.350–1.233)	0.188*	0.724 (0.368–1.463)	0.350

ISSN: 1471-2407