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Table 2 Univariable cox analysis of risk factors for early recurrence of HCC

From: Preoperative risk stratification for early recurrence of HBV-related hepatocellular carcinoma after deceased donor liver transplantation: a five-eight model development and validation

Variable

2-year recurrence rate

HR

SE

z

P > z

95% CI

Age (52/≤52 years)

17.6/16.4

0.98

0.25

0.07

0.942

0.59–1.63

Gender (male/female)

17.9/9.2

1.51

0.78

0.80

0.426

0.55–4.16

Diabetes (yes/no)

19.4/17.1

0.79

0.34

0.55

0.585

0.34–1.84

Hypertension (yes/no)

24.7/16.3

1.54

0.59

1.14

0.253

0.73–3.25

BMI (25/≤25)

18.5/16.4

0.99

0.28

0.05

0.959

0.561.73

CTP class(A/B/C)

19.5/14.9/15.3

0.94

0.16

0.38

0.705

0.67–1.31

MELD (12/≤12)

13.7/20.2

0.81

0.21

0.81

0.416

0.49–1.35

Cirrhosis (yes/no)

17.414.2

1.24

0.47

0.57

0.566

0.59–2.62

Pre-LT AFP (ng/mL) (Reference, ≤10)

 10–200

19.5

3.57

1.65

2.75

0.006

1.44–8.83

 201–1000

21.8

4.65

2.29

3.11

0.002

1.77–12.23

  > 1000

39.2

9.03

4.20

4.72

< 0.001

3.62–22.49

Total tumor diameter (cm) (Reference, ≤5)

 5–8

21.9

3.20

1.19

3.13

0.002

1.55–6.64

  > 8

52.6

8.89

2.88

6.75

< 0.001

4.7116.76

Largest tumor diameter (cm) (Reference, ≤4)

 4–6

21.8

2.37

0.90

2.28

0.023

1.13–4.98

 6–8

28.2

3.67

1.55

3.08

0.002

1.61–8.39

  > 8

74.8

10.49

3.31

7.45

< 0.001

5.65–19.46

Nodules number (single/multiple)

12.3/24.6

1.883142

.4874233

2.45

0.014

1.13–3.13

Pre-LT TACE (yes/no)

23.3/13.0

2.03

0.53

2.73

0.006

1.22–3.39

Pre-LT RFA (yes/no)

13.6/18.0

0.79

0.29

0.65

0.519

0.39–1.61

Pre-LT hepatectomy (yes/no)

25.0/15.5

1.59

0.49

1.52

0.128

0.88–2.90

Vascular invasion (yes/no)

43.0/9.8

4.31

1.12

5.62

< 0.001

2.59–7.17

Differentiation (Reference, well)

 moderate

14.9

1.52

0.67

0.95

0.344

0.64–3.59

 poor

26.1

2.81

1.35

2.16

0.031

1.10–7.19

 Milan criteria (out/in)

33.8/4.8

7.68

2.78

5.64

< 0.001

3.78–15.62

 Hangzhou criteria (out/in)

57.5/9.1

7.24

1.91

7.52

< 0.001

4.32–12.13

 AFP model (out/in)

35.0/7.9

5.80

1.73

5.89

< 0.001

3.23–10.41

  1. Note: BMI Body mass index, CTP Child-Turcotte-Pugh, AFP Alpha-fetoprotein, MELD Model for End-Stage Liver Disease, LT Liver transplantation, TACE Transarterial chemoembolization, RFA Radiofrequency ablation