Fig. 1

a Hierarchical clustering of the 100 most differentially regulated genes between primary EOC samples and their matching omental metastases based on average correlation of the log2 expression values (rpkm). Red = primary tumor, blue = metastasis. The image was generated using Java Treeview 1.1.6r4 [17] b Volcano plot of log2 fold change and -log10 (FDR) of the differentially regulated genes demonstrated that majority of the genes are downregulated in the omental samples. c IPA® gene ontology analysis of the genes demonstrated that cellular functions related to embryonic development and vasculogenesis were decreased whereas those related to organismal survival, cellular maintenance and proliferation were increased. d IPA® analysis of upstream transcription regulators identified activation of the TP53 and inhibition of the BMP7 pathways. Blue color stands for predicted inhibition and orange for predicted activation. The tones of color indicate confidence level (light = low confidence; dark = high confidence).