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Fig. 4 | BMC Cancer

Fig. 4

From: Tumor suppressor HIC1 is synergistically compromised by cancer-associated fibroblasts and tumor cells through the IL-6/pSTAT3 axis in breast cancer

Fig. 4

CAF-derived IL-6 decreased HIC1 expression in SK-BR-3 cells. HIC1 was decreased in SK-BR-3 cells cocultured with CAF40 and CAF74 compared to cells cocultured with NAF1. b-c HIC1 was decreased in SK-BR-3 by rhIL-6 in a time- and dose-dependent manner. d The decreased HIC1 induced by rhIL-6 was completely restored by STAT3 inhibition

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BMC Cancer

ISSN: 1471-2407

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