Table 2 Clinicopathological patient characteristics
All cases | HER2-neg. | HER2-pos. | p-value | ||
|---|---|---|---|---|---|
Number (%) | 436 (100) | 430 (98.6) | 6 (1.4) | ||
Age | range (years) | 24.4–88.2 | 24.4–88.2 | 45.8–79.9 | |
median (years) | 66.3 | 66.2 | 71.3 | 0.520 | |
Sex | male | 279 (64) | 276 (64) | 3 (50) | 0.672 |
female | 157 (36) | 154 (36) | 3 (50) | ||
CCA subgroups | iCCA | 155 (36) | 154 (99) | 1 (1) | 0.459 |
pCCA | 155 (36) | 153 (99) | 2 (1) | ||
dCCA | 126 (28) | 123 (98) | 3 (2) | ||
Histology | ductal | 296 (68) | 291 (68) | 5 (83) | 0.852 |
solid | 56 (13) | 56 (13) | 0 (0) | ||
papillary | 23 (5) | 22 (5) | 1 (17) | ||
signet ring | 21 (5) | 21 (5) | 0 (0) | ||
mucinous | 16 (4) | 16 (4) | 0 (0) | ||
clear cell | 14 (3) | 14 (3) | 0 (0) | ||
adenosquamous | 6 (1) | 6 (1) | 0 (0) | ||
intestinal | 4 (1) | 4 (1) | 0 (0) | ||
UICC stage | UICC 1 | 14 (4) | 14 (4) | 0 (0) | 0.236 |
UICC 2 | 123 (36) | 119 (36) | 4 (80) | ||
UICC 3 | 184 (54) | 183 (55) | 1 (20) | ||
UICC 4 | 18 (6) | 18 (5) | 0 (0) | ||
NA | 97 | 96 | 1 | ||
pT | T1 | 29 (7) | 29 (7) | 0 (0) | 0.586 |
T2 | 247 (56) | 242 (56) | 5 (83) | ||
T3 | 131 (30) | 130 (30) | 1 (17) | ||
T4 | 29 (7) | 29 (7) | 0 (0) | ||
pN | N0 | 166 (49) | 162 (49) | 4 (80) | 0.386 |
N1 | 169 (51) | 168 (51) | 1 (20) | ||
N2 | 1 (0) | 1 (0) | 0 (0) | ||
NX | 100 | 99 | 1 | ||
pM | MX | 418 (96) | 412 (96) | 6 (100) | 1.000 |
M1 | 18 (4) | 18 (4) | 0 (0) | ||
G | G1 | 16 (4) | 16 (4) | 0 (0) | 0.857 |
G2 | 301 (69) | 297 (69) | 4 (67) | ||
G3 | 119 (27) | 117 (27) | 2 (33) | ||
L | L0 | 197 (45) | 192 (45) | 5 (80) | 0.059 |
L1 | 239 (55) | 238 (55) | 1 (20) | ||
V | V0 | 223 (51) | 220 (51) | 3 (50) | 0.955 |
V1 | 213 (49) | 210 (49) | 3 (50) | ||
Pn | Pn0 | 173 (40) | 169 (39) | 4 (67) | 0.174 |
Pn1 | 263 (60) | 261 (61) | 2 (33) | ||
R | R0 | 185 (51) | 182 (50) | 3 (100) | 0.230 |
R1 | 175 (48) | 175 (48) | 0 (0) | ||
R2 | 5 (1) | 5 (2) | 0 (0) | ||
RX | 71 | 68 | 3 |