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Fig. 2 | BMC Cancer

Fig. 2

From: HER2 gene (ERBB2) amplification is a rare event in non-liver-fluke associated cholangiocarcinogenesis

Fig. 2

HER2 positivity in high-grade biliary intraepithelial neoplasia. All cases with HER2 negativity in the invasive cholangiocarcinoma component also lacked HER2 positivity in concomitant high-grade precursor lesions (biliary intraepithelial neoplasia, grade 3) (a). Four of five cases with available concomitant precursor lesions exhibited HER2 positivity already in biliary intraepithelial neoplasia, grade 3 (b). Note the abrupt change in HER2 staining from non-dysplastic to dysplastic epithelium (arrowhead). Original magnification A-B [400x]

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BMC Cancer

ISSN: 1471-2407

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