Fig. 2

Influence of decreased miR-155 on 8305c and FRO cell proliferation, invasion, and apoptosis. a 8305c and FRO cells were instantaneous transfection with miR-155 ASO or negative control (8305c: 1.57 ± 0.11 vs. 3.46 ± 0.09 [control], P = 0.005; FRO: 1.26 ± 0.04 vs. 3.82 ± 0.08 [control], P < 0.001). b Cell survival rates in MTT assay in miR-155-suppressed and control 8305c and FRO cells. The rate of increase in cell number decreased in miR-155-suppressed cells was found (8305c: 11.7% ± 2.1, 21.7% ± 2.6, 20.0% ± 3.2 and 34.9% ± 3.9 at 24, 48, 72, and 96 h, respectively, P = 0.037; FRO: 12.9% ± 1.7, 25.8% ± 2.3, 28.5% ± 3.6 and 36.3% ± 4.2 at 24, 48, 72, and 96 h, separately, P = 0.023). cTypical photo (upper; zoom in 200 times) and fixed quantity discuss (bottom) of determination of Transwell mobile and aggressive attacks in miR-155-suppressed and negative dominate 8305c and FRO cells. d Typical photo and rate of aging death of miR-155-suppressed or negative control 8305c and FRO cells (**P = 0.009 and P = 0.005 for 8305c and FRO cells, respectively). e Caspase-3 activity in miR-155-suppressed or negative control 8305c and FRO cells (*P = 0.031 and P = 0.044 for 8305c and FRO cells, respectively). All trials are done three times