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Fig. 1 | BMC Cancer

Fig. 1

From: Frozen section accurately allows pathological characterization of endometrial cancer in patients with a preoperative ambiguous or inconclusive diagnoses: our experience

Fig. 1

Graphic representation of the differences observed concerning histotype, grading, cervical involvent and myometrial invasion between intraoperative evaluation and final diagnosis. a) Histotype: 175/180 lesions considered intraoperatively as Endometrioid Adenocarcinoma (EA) were confirmed in final surgical reports; the remaining 5 cases, with an intraoperative diagnosis of EA, were then diagnosed as Non Endometrioid Adenocarcinoma (NEC) on permanent section; on frozen section, 22 diagnoses of NEC were performed, with 13/22 cases confirmed in definitive evaluation. (EA-I: Endometrioid Adenocarcinoma-Intraoperative; EA-D: Endometrioid Adenocarcinoma-Definitive; NEC-I: Non Endometrioid Adenocarcinoma-Intraoperative; NEC-D: Non- Endometrioid Adenocarcinoma-Definitive). b) Grade: 139/157 lesions considered intraoperatively as Low grade were confirmed in final surgical reports; the remaining 18 cases, with an intraoperative diagnosis of Low-grade adenocarcinoma, were then diagnosed as High Grade on permanent section; on frozen section 45 diagnoses of High Grade carcinoma were performed, all confirmed in definitive diagnosis. (LG-I: Low Grade-Intraoperative; LG-D: Low Grade-Definitive; HG-I: High Grade-Intraoperative; HG-D: High Grade-Definitive). c) Miometrial invasion: 139/155 lesions evaluated as mioinvasive ≥50% were confirmed in the final diagnosis; the remaining 16 cases, with an intraoperative diagnosis of mioinvasion < 50%, were then diagnosed as mioinfiltrative > 50% on permanent section; on frozen section 47 diagnoses of mioinvasion ≥50% were performed, 41 of which confirmed in definitive diagnosis. (≥50-I: Mioinvasion ≥ 50% Intraoperative; ≥50-D: Mioinvasion ≥ 50% Definitive; < 50-D: Mioinvasion < 50% Intraoperative; < 50-D: Mioinvasion < 50% Definitive). d) Cervical involvement: 10 carcinomas intraoperatively considered with cervical invasion were all confirmed in definitive diagnosis; on frozen section, 192 diagnoses of negative cervical involvement were made, 183 of which confirmed in definitive diagnosis. (CI-I: Cervical Involvement intraoperative; CI-D: Cervical Involvement Definitive; NCI-I: Non Cervical Involvement Intraoperative; NCI-D: Non Cervical Involvement Definitive)

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