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Table 3 Clinical characteristics of familial lung cancer cases curated in Table 2

From: Potential genetic modifiers for somatic EGFR mutation in lung cancer: a meta-analysis and literature review

CharacteristicsAllGermline EGFR carrier
Case No.4122
Age at diagnosis
Median (range)57 (22-78)57 (29–78)
Gender
 Male10 (24.4%)5 (22.7%)
 Female31 (75.6%)17 (77.3%)
Smoking Status
 Smoking a11 (26.8%)8 (36.4%)
 Non-smoking24 (58.5%)10 (43.5%)
 Not reported6 (14.6%)4 (18.1%)
Family No.2914
 Ethnicity29 (100.0%)14 (100.0%)
  White8 (27.6%)5 (35.7%)
  Asian7 (24.1%)2 (14.3%)
  Other4 (13.8%)2 (14.3%)
  Not reported10 (34.5%)5 (35.7%)
Multiple lung tumours10 (34.5%)6 (42.9%)
Lung tumour No. b≥7847
Histology (by tumour)
 Adenocarcinoma72 (~ 92.3%)41 (87.2%)
 Other c6 (~ 7.7%)6 (12.8%)
Somatic co-occurring EGFR mutation status
 Mutatedd54 (69.2%)33 (70.2%)
 L858R26 (48.1%)19 (57.6%)
 Exon 19del11 (20.4%)4 (8.5%)
 Other12 (22.2%)10 (30.3%)
  1. aIncluding both light smokers and smokers in Table 2
  2. bDetailed number of lung tumours were not available in some cases diagnosed with “multiple lung cancers”, thus we recorded their number as ≥2 per case. The tumour number in Case #9 in Family #7 was recorded as one due to incomplete information regarding other pre-cancerous and pre-invasive lesions in the lung
  3. cIncluding five non-small cell lung cancers and one squamous cell lung cancer
  4. dWe recorded the mutated tumours in Case #29 in Family #17 as two (one L858R and the other 19del) due to no detailed information. Other mutations included G719C/S/A and exon 20 insertions