Table 1 Gene Ontology Pathway Enrichment Analysis of level 5 communities of ovarian cancer network
S. No. | Community | Pathway | Identifier | Reference Pathway | Genes | p-value | Benjamini corrected p-value |
|---|---|---|---|---|---|---|---|
1. | C32121 | Rap1 signalling pathway | hsa04015 | KEGG | PIK3CG, RASSF5, PLCB3, KRAS, RAC2, RASGRP2, RAC1, RALGDS | 3.9E-5 | 5.5E-3 |
2. | C32122 | PI3K-Akt signalling pathway | hsa04151 | KEGG | IL2RB, IL2RA, PDGFB, PIK3CB, PPP2R5C, TCL1A, NR4A1, TCL1B, BAD, BCL2L11, AKT1, EIF4EBP1, TSC1, PDGFRB, RELN, MTCP1, NOS3, IL2RG, JAK3, IKBKB, THEM4, IL2 | 4.9E-11 | 7.3E-9 |
3. | C32123 | Proteoglycans in cancer | hsa05205 | KEGG | CDC42, ANK1, EZR, CD44, CAMK2G, RRAS, ITGB5, ITGA2, MSN, FLNC, CD63 | 2.3E-7 | 2.6E-5 |