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Table 4 Stratified multivariable Cox model analyses

From: Relationship between WBRT total dose, intracranial tumor control, and overall survival in NSCLC patients with brain metastases - a single-center retrospective analysis

BM LesionsWBRT (Gy)OSiPFS
HR95%CIpaHR95%CIpa
1–3
(N1 = 338)
none1.000 ref.1.000 ref.
< 301.607(0.876–2.946)0.1251.660(0.915–3.009)0.095
30–390.781(0.432–1.413)ns0.700(0.408–1.201)0.196
≥400.639(0.403–1.012)0.0560.592(0.380–0.924)0.021
 ≥40 vs. 30–39 (ref.)0.818(0.456–1.466)0.4990.846(0.505–1.417)0.526
≥4
(N2 = 257)
none1.000 ref.1.000 ref.
< 300.977(0.487–1.957)ns1.880(0.915–3.863)0.086
30–390.589(0.348–0.996)0.0480.699(0.421–1.159)0.165
≥400.514(0.328–0.806)0.0040.624(0.401–0.969)0.036
 ≥40 vs. 30–39 (ref.)0.873(0.540–1.413)0.5810.892(0.558–1.426)0.634
  1. BM brain metastases; WBRT whole brain radiotherapy; OS overall survival; iPFS intracranial progression-free survival; HR hazard ratio; 95%CI 95% confidence interval; ns not significant with p >0.20; ref. reference
  2. a from the multivariable Cox model analysis without BM lesion group as one covariate