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Fig. 8 | BMC Cancer

Fig. 8

From: CRL4 ubiquitin ligase stimulates Fanconi anemia pathway-induced single-stranded DNA-RPA signaling

Fig. 8

Scheme describing the function of CRL4 in protecting cancer cells from ICL cytotoxicity. The results of Figs. 3, 4, 5 and 6 indicate that CRL4 stimulates the FA pathway-dependent ubiquitination of the FANCI-FANCD2 complex, which is necessary for the recruitment of nucleases to ICL sites [8, 31, 32]. In turn, nuclease activity at ICLs generates a ssDNA-RNA platform for activation of an ATR-dependent cell cycle checkpoint signaling leading to S phase arrest. This findings imply that CRL4 provides a potential target for the sensitization of cancer cells to crosslinking drugs

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