Table 1 Differential diagnosis of thrombocytopenia
From: Teetering on a liver’s edge: a case report highlighting clinical decision-making in thrombocytopenia
A) Diminished Platelet Production | -Marrow infiltration |
-Marrow injury | |
-Infection | |
-Genetic syndromes (rare) | |
B) Shortened Platelet Life Span -Immune Mediated -Nonimmune Mediated | -Immune thrombocytopenic purpura (ITP) |
-Neonatal alloimmune thrombocytopenia | |
-Infection | |
-Heparin induced thrombocytopenia | |
-Drug or vaccine induced | |
-Systemic autoimmune disease | |
-Disseminated intravascular coagulation | |
-Hemolytic uremic syndrome | |
-Thrombotic thrombocytopenic purpura | |
-Major surgery or trauma | |
-Infection | |
C) Platelet Sequestration or Pooling | -Hypersplenism |
-Kasabach-Merritt phenomenon | |
-Chronic liver or storage disease | |
-Portal vein thrombosis | |
-Von Willebrand disease (type 2B and platelet-type) | |
D) Platelet dilution | -Massive transfusion of packed red blood cells or whole blood |