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Table 1 Differential diagnosis of thrombocytopenia

From: Teetering on a liver’s edge: a case report highlighting clinical decision-making in thrombocytopenia

A) Diminished Platelet Production-Marrow infiltration
-Marrow injury
-Genetic syndromes (rare)
B) Shortened Platelet Life Span
-Immune Mediated
-Nonimmune Mediated
-Immune thrombocytopenic purpura (ITP)
-Neonatal alloimmune thrombocytopenia
-Heparin induced thrombocytopenia
-Drug or vaccine induced
-Systemic autoimmune disease
-Disseminated intravascular coagulation
-Hemolytic uremic syndrome
-Thrombotic thrombocytopenic purpura
-Major surgery or trauma
C) Platelet Sequestration or Pooling-Hypersplenism
-Kasabach-Merritt phenomenon
-Chronic liver or storage disease
-Portal vein thrombosis
-Von Willebrand disease (type 2B and platelet-type)
D) Platelet dilution-Massive transfusion of packed red blood cells or whole blood